ArticleAIDS research and human retroviruses2013
Acute HIV-1 infection in the Southeastern United States: a cohort study.
Article in AIDS research and human retroviruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Sex, age, race and intervention type in clinical studies of HIV cure: a systematic review.AIDS research and human retroviruses · 2015Pooled it
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- LGBTQ+ Youth Health: An Unmet Need in Pediatrics.Children (Basel, Switzerland) · 2022Review
- Adolescents and Young Adults: The Pediatrician's Role in HIV Testing and Pre- and Postexposure HIV Prophylaxis.Pediatrics · 2022Article
- Ethical considerations for HIV remission clinical research involving participants diagnosed during acute HIV infection.BMC medical ethics · 2021Article
- Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection.AIDS (London, England) · 2020Article
- Phylodynamic Analysis Complements Partner Services by Identifying Acute and Unreported HIV Transmission.Viruses · 2020Article
- HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Leveraging Phylogenetics to Understand HIV Transmission and Partner Notification Networks.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- A Simple Symptom Score for Acute Human Immunodeficiency Virus Infection in a San Diego Community-Based Screening Program.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Differences in acute retroviral syndrome by HIV-1 subtype in a multicentre cohort study in Africa.AIDS (London, England) · 2017Article
- Development and validation of a risk score to assist screening for acute HIV-1 infection among men who have sex with men.BMC infectious diseases · 2017Article
- Human Immunodeficiency Virus, Other Sexually Transmitted Infections, and Sexual and Reproductive Health in Lesbian, Gay, Bisexual, Transgender Youth.Pediatric clinics of North America · 2016Review
- Fixed-dose combination emtricitabine/tenofovir/efavirenz initiated during acute HIV infection; 96-week efficacy and durability.AIDS (London, England) · 2016Article
- Thrombotic microangiopathy as first manifestation of acute human immunodeficiency virus infection: a case report and review of the literature.Journal of medical case reports · 2016Review
- Ten Years of Screening and Testing for Acute HIV Infection in North Carolina.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Phylogenetic Investigation of a Statewide HIV-1 Epidemic Reveals Ongoing and Active Transmission Networks Among Men Who Have Sex With Men.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- The HIV treatment cascade in acutely infected people: informing global guidelines.Current opinion in HIV and AIDS · 2015Review
- Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Incidence of HIV and the prevalence of HIV, hepatitis B and syphilis among youths in Maputo, Mozambique: a cohort study.PloS one · 2015Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
In 1998 a collaboration between Duke University and the University of North Carolina, Chapel Hill (UNC) was founded to enhance identification of persons with acute HIV-1 infection (AHI). The Duke-UNC AHI Research Consortium Cohort consists of patients ≥18 years old with a positive nucleic acid amplification test (NAAT) and either a negative enzyme immunoassay (EIA) test or a positive EIA with a negative/indeterminate Western blot. Patients were referred to the cohort from acute care settings and state-funded HIV testing sites that use NAAT testing on pooled HIV-1 antibody-negative samples. Between 1998 and 2010, 155 patients with AHI were enrolled: 81 (52%) African-Americans, 63 (41%) white, non-Hispanics, 137 (88%) males, 108 (70%) men who have sex with men (MSM), and 18 (12%) females. The median age was 27 years (IQR 22-38). Most (n=138/155) reported symptoms with a median duration of 17.5 days. The median nadir CD4 count was 408 cells/mm(3) (IQR 289-563); the median observed peak HIV-1 level was 726,859 copies/ml (IQR 167,585-3,565,728). The emergency department was the most frequent site of initial presentation (n=55/152; 3 missing data). AHI diagnosis was made at time of first contact in 62/137 (45%; 18 missing data) patients. This prospectively enrolled cohort is the largest group of patients with AHI reported from the Southeastern United States. The demographics reflect the epidemic of this geographic area with a high proportion of African-Americans, including young black MSM. Highlighting the challenges of diagnosing AHI, less than half of the patients were diagnosed at the first healthcare visit. Women made up a small proportion despite increasing numbers in our clinics.
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Registered trials
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