Trial reportJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2012
Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance.
Trial report in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 229 citations in OpenAlex.
- Pharmacotherapy for hypertension-induced left ventricular hypertrophy.The Cochrane database of systematic reviews · 2021Pooled it
- Epicardial adipose tissue, myocardial remodelling and adverse outcomes in asymptomatic aortic stenosis: a post hoc analysis of a randomised controlled trial.Heart (British Cardiac Society) · 2025Trial
- CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases.Circulation · 2021Trial
- Prospective association between handgrip strength and cardiac structure and function in UK adults.PloS one · 2018Trial
- Challenges in diagnosis and management of severe aortic stenosis with coexisting cardiac amyloidosis: a case report.European heart journal. Case reports · 2026Article
- A structured 5-question approach for echocardiographic evaluation of undifferentiated shock.Echo research and practice · 2026Review
- Article
- Progression of stenosis severity and aortopathy in adult patients with congenital aortic stenosis.International journal of cardiology. Congenital heart disease · 2026Article
- Interpreting a Thick Myocardium on Cardiac MR: A Practical Guide for Radiologists.Journal of the Korean Society of Radiology · 2026Review
- Prognostic value of left ventricular phenotypes by cardiac magnetic resonance in elderly and non-elderly patients.Journal of geriatric cardiology : JGC · 2026Article
- Longitudinal Changes in Left Ventricular Geometry After Kidney Transplantation and Their Implications on Cardiovascular Risk.Kidney medicine · 2026Article
- Sex-specific association of epicardial adipose tissue thickness and left ventricular hypertrophy in the older adults-cross-sectional results from the population-based AugUR study.Frontiers in cardiovascular medicine · 2026Article
- Left ventricular diastolic volume on cardiac magnetic resonance and risk of incident heart failure.European heart journal open · 2026Article
- Cardiac magnetic resonance characteristics and prognostic associations of hypertension-mediated left ventricular hypertrophy.European heart journal. Imaging methods and practice · 2026Article
- Patients with paradoxical low-flow, low-gradient aortic stenosis gain the least benefit from TAVI among all hemodynamic subtypes.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Small left ventricular size as a predictor for incident type 2 diabetes: insights from the UK biobank cardiovascular magnetic resonance substudy.Diabetology & metabolic syndrome · 2025Article
- Left ventricular wall thickness heterogeneity improves cardiovascular disease diagnosis and prognosis: a UK Biobank cardiovascular magnetic resonance cohort study.European heart journal. Imaging methods and practice · 2025Article
- Utility of Serum Biomarkers of Myocardial Fibrosis in High-Gradient Severe Aortic Stenosis: An Explorative Cardiovascular Magnetic Resonance Imaging-Based Study.Diagnostics (Basel, Switzerland) · 2025Article
- Cardiac rehabilitation for TAVR patients: mechanisms, current status, and future directions.Frontiers in cardiovascular medicine · 2025Review
- Differentiating Left Ventricular Remodeling in Aortic Stenosis From Systemic Hypertension.Circulation. Cardiovascular imaging · 2024Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCardiovascular magnetic resonance (CMR) is the gold standard non-invasive method for determining left ventricular (LV) mass and volume but has not been used previously to characterise the LV remodeling response in aortic stenosis. We sought to investigate the degree and patterns of hypertrophy in aortic stenosis using CMR.
methodsPatients with moderate or severe aortic stenosis, normal coronary arteries and no other significant valve lesions or cardiomyopathy were scanned by CMR with valve severity assessed by planimetry and velocity mapping. The extent and patterns of hypertrophy were investigated using measurements of the LV mass index, indexed LV volumes and the LV mass/volume ratio. Asymmetric forms of remodeling and hypertrophy were defined by a regional wall thickening ≥ 13 mm and >1.5-fold the thickness of the opposing myocardial segment.
resultsNinety-one patients (61 ± 21 years; 57 male) with aortic stenosis (aortic valve area 0.93 ± 0.32 cm2) were recruited. The severity of aortic stenosis was unrelated to the degree (r2=0.012, P=0.43) and pattern (P=0.22) of hypertrophy. By univariate analysis, only male sex demonstrated an association with LV mass index (P=0.02). Six patterns of LV adaption were observed: normal ventricular geometry (n=11), concentric remodeling (n=11), asymmetric remodeling (n=11), concentric hypertrophy (n=34), asymmetric hypertrophy (n=14) and LV decompensation (n=10). Asymmetric patterns displayed considerable overlap in appearances (wall thickness 17 ± 2mm) with hypertrophic cardiomyopathy.
conclusionsWe have demonstrated that in patients with moderate and severe aortic stenosis, the pattern of LV adaption and degree of hypertrophy do not closely correlate with the severity of valve narrowing and that asymmetric patterns of wall thickening are common.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.