ArticleBMC cancer2012
Nutrition deficiency increases the risk of stomach cancer mortality.
Article in BMC cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Famine Exposure during Early Life and Risk of Cancer in Adulthood: A Systematic Review and Meta-Analysis.The journal of nutrition, health & aging · 2023Pooled it
- Systematic review on chronic non-communicable disease in disaster settings.BMC public health · 2022Pooled it
- A Systematic Literature Review and Meta-Regression Analysis on Early-Life Energy Restriction and Cancer Risk in Humans.PloS one · 2016Pooled it
- Early-life undernutrition increases the risk of death from chronic diseases in adulthood: a population-based cohort study.Global health research and policy · 2025Article
- Preoperative Glutamine Supplementation in Gastric Cancer-Thrombocyte Phagocytic Activity and Early Postoperative Outcomes.Nutrients · 2023Article
- Prognostic artificial intelligence model to predict 5 year survival at 1 year after gastric cancer surgery based on nutrition and body morphometry.Journal of cachexia, sarcopenia and muscle · 2023Article
- Prenatal exposure to famine and the development of diabetes later in life: an age-period-cohort analysis of the China health and nutrition survey (CHNS) from 1997 to 2015.European journal of nutrition · 2023Article
- The Prognostic Value of the GNRI in Patients with Stomach Cancer Undergoing Surgery.Journal of personalized medicine · 2023Article
- Association of Famine Exposure on the Changing Clinical Phenotypes of Primary Hyperparathyroidism in 20 years.Frontiers in endocrinology · 2022Article
- Urban-rural disparity in cancer mortality and changing trend in Tianjin, China, during 1999 and 2016.BMC cancer · 2021Article
- Association of Symptoms with Eating Habits and Food Preferences in Chronic Gastritis Patients: A Cross-Sectional Study.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Influence of socioeconomic events on cause-specific mortality in urban Shanghai, China, from 1974 to 2015: a population-based longitudinal study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- PALTEM: What Parameters Should Be Collected in Disaster Settings to Assess the Long-Term Outcomes of Famine?International journal of environmental research and public health · 2018Review
- Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India.BMC cancer · 2017Article
- Time trends of esophageal and gastric cancer mortality in China, 1991-2009: an age-period-cohort analysis.Scientific reports · 2017Article
- Elevated levels of protein in urine in adulthood after exposure to the Chinese famine of 1959-61 during gestation and the early postnatal period.International journal of epidemiology · 2014Article
- Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer.PloS one · 2014Article
- Clinical Significance of the Geriatric Nutritional Risk Index in the Evaluation of Outcomes of Patients After Radical Gastrectomy.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of the study is to determine whether exposure to malnutrition during early life is associated with increased risk of stomach cancer in later life.
methodsThe design protocol included analyzing the trend of gastric cancer mortality and nutrition and evaluating the association between nutrient deficiency in early life and the risk of gastric cancer by hierarchical age-period-birth cohort (APC) analysis using general log-linear Poisson models and to compare the difference between birth cohorts who were exposed to the 1959-1961 Chinese famine and those who were not exposed to the famine. Data on stomach cancer mortality from 1970 to 2009 and the dietary patterns from 1955 to 1985 which included the 1959-1961 Chinese famine period in the Zhaoyuan County population were obtained. The nutrition information was collected 15 years prior to the mortality data as based on the latest reference of disease incubation.
resultsAPC analysis revealed that severe nutrition deficiency during early life may increase the risk of stomach cancer. Compared with the 1960-1964 birth cohort, the risk for stomach cancer in all birth cohorts from 1900 to 1959 significantly increased; compared with the 1970-1974 cohort, the risk for stomach cancer in the 1975-1979 cohort significantly increased, whereas the others had a steadily decreased risk; compared with 85-89 age group in the 2005-2009 death survey, the ORs decreased with younger age and reached significant levels for the 50-54 age group after adjusting the confounding factors. The 1930 to 1964 group (exposed to famine) had a higher mortality rate than the 1965 to 1999 group (not exposed to famine). For males, the relative risk (RR) was 2.39 and the 95% confidence interval (CI) was 1.51 to 3.77. For females, RR was 1.64 and 95% CI was 1.02 to 2.62.
conclusionThe results of the present study suggested that prolonged malnutrition during early life may increase the risk of stomach cancer mortality in later life.
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