ArticleInternational journal of critical illness and injury science2012
Immunoregulation of bone remodelling.
Article in International journal of critical illness and injury science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- The Osteoimmune Axis: Immune-Mechanical Crosstalk in Periodontal Bone Remodeling.Biomolecules · 2026Article
- Immune-Guided Bone Healing: The Role of Osteoimmunity in Tissue Engineering Approaches.International journal of molecular sciences · 2025Review
- Genome-Wide Association Study of Morphological Defects in Nellore Cattle Using a Binary Trait Framework.Genes · 2025Article
- Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective.International journal of molecular sciences · 2024Review
- From gut to bone: deciphering the impact of gut microbiota on osteoporosis pathogenesis and management.Frontiers in cellular and infection microbiology · 2024Review
- Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration.Bioactive materials · 2023Review
- Protective effects of curcumin against osteoporosis and its molecular mechanisms: a recent review in preclinical trials.Frontiers in pharmacology · 2023Review
- Macrophages-bone marrow mesenchymal stem cells crosstalk in bone healing.Frontiers in cell and developmental biology · 2023Review
- FOXO1 expression in chondrocytes modulates cartilage production and removal in fracture healing.Bone · 2021Article
- Development of Metabolic Syndrome Decreases Bone Mineral Density T-Score of Calcaneus in Foot in a Large Taiwanese Population Follow-Up Study.Journal of personalized medicine · 2021Article
- Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation.Physiological reports · 2021Article
- Effects of CD4Experimental and therapeutic medicine · 2020Article
- Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies.Molecules (Basel, Switzerland) · 2020Review
- Biological basis of bone strength: anatomy, physiology and measurement.Journal of musculoskeletal & neuronal interactions · 2020Review
- Relationship Between Metabolic Syndrome and Bone Health - An Evaluation of Epidemiological Studies and Mechanisms Involved.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Polyphenol uses in biomaterials engineering.Biomaterials · 2018Review
- Impairment of early fracture healing by skeletal muscle trauma is restored by FK506.BMC musculoskeletal disorders · 2017Article
- Allium cepa L. and Quercetin Inhibit RANKL/Porphyromonas gingivalis LPS-Induced Osteoclastogenesis by Downregulating NF-κB Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Periodontal disease immunology: 'double indemnity' in protecting the host.Periodontology 2000 · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remodeling, a continuous physiological process maintains the strength of the bones, which maintains a delicate balance between bone formation and resorption process. This review gives an insight to the complex interaction and correlation between the bone remodeling and the corresponding changes in host immunological environment and also summarises the most recent developments occuring in the understanding of this complex field. T cells, both directly and indirectly increase the expression of receptor activator of nuclear factor kB ligand (RANKL); a vital step in the activation of osteoclasts, thus positively regulates the osteoclastogenesis. Though various cytokines, chemikines, transcription factors and co-stimulatory molecules are shared by both skeletal and immune systems, but researches are being conducted to establish and analyse their role and / or control on this complex but vital process. The understanding of this part of research may open new horizons in the management of inflammatory and autoimmune diseases, resulting into bone loss and that of osteoporosis also.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.