Evidence map›Paper›PMID 22837879›Full record

ArticleJournal of neurogastroenterology and motility2012

Does acupuncture therapy alter activation of neural pathway for pain perception in irritable bowel syndrome?: a comparative study of true and sham acupuncture using functional magnetic resonance imaging.

Winnie Cw Chu, Justin Cy Wu, David Tw Yew, Liang Zhang, Lin Shi, David Kw Yeung, Defeng Wang, Raymond Ky Tong, Yawen Chan, Lixing Lao and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurogastroenterology and motility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
9.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  20. Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review.Evidence-based complementary and alternative medicine : eCAM · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Winnie Cw ChuDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.
Justin Cy Wu
David Tw Yew
Liang Zhang
Lin Shi
David Kw Yeung
Defeng Wang
Raymond Ky Tong
Yawen Chan
Lixing Lao
Ping C Leung
Brian M Berman
Joseph Jy Sung
Chinese University of Hong Kong · HKDigestive Health Research Institute · FRSociety of Interventional Radiology · USUniversity of Maryland, Baltimore · USHong Kong Polytechnic University · HK

Funding

Project 3 - A Dose-Ranging Study of Chinese Herbal Medicine in Treating PatientsU19AT003266 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI BERMAN, BRIAN M · 2005 to 2009
$4.5M
NCCIH NIH HHS U19 AT003266
6 · The paper itself

Abstract

BACKGROUND/

aimsPatients with irritable bowel syndrome (IBS) are characterized by abnormal central processing with altered brain activation in response to visceral nociceptive signals. The effect of electroacupuncture (EA) on IBS patients is unclear. The study is set to study the effect of EA on brain activation during noxious rectal distension in IBS patients using a randomized sham-controlled model.

methodsThirty IBS-diarrhea patients were randomized to true electroacupuncture or sham acupuncture. Functional MRI was performed to evaluate cerebral activation at the following time points: (1) baseline when there was rectal distension only, (2) rectal distension during application of EA, (3) rectal distension after cessation of EA and (4) EA alone with no rectal distension. Group comparison was made under each condition using SPM5 program.

resultsRectal distension induced significant activation of the anterior cingulated cortex, prefrontal cortex, thalamus, temporal regions and cerebellum at baseline. During and immediately after EA, increased cerebral activation from baseline was observed in the anterior cingulated cortex, bilateral prefrontal cortex, thalamus, temporal regions and right insula in both groups. However, true electroacupuncture led to significantly higher activation at right insula, as well as pulvinar and medial nucleus of the thalamus when compared to sham acupuncture.

conclusionsWe postulate that acupuncture might have the potential effect of pain modulation in IBS by 2 actions: (1) modulation of serotonin pathway at insula and (2) modulation of mood and affection in higher cortical center via ascending pathway at the pulvinar and medial nucleus of the thalamus.

Indexed as

AcupunctureIrritable bowel syndromeMagnetic resonance imaging

Identifiers

PMID22837879
PMCPMC3400819
OpenAlexW2151282185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.