ArticlePulmonary circulation
Leptin levels predict survival in pulmonary arterial hypertension.
Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Novel Hemodynamic, Vascular Lesion, and Cytokine/Chemokine Differences Regarding Sex in a Pulmonary Arterial Hypertension Model.American journal of respiratory cell and molecular biology · 2024Article
- Adipokines in pulmonary hypertension: angels or demons?Heliyon · 2023Review
- A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific.Frontiers in medicine · 2023Article
- The Glycobiology of Pulmonary Arterial Hypertension.Metabolites · 2022Review
- Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications.Physiological reviews · 2021Review
- A targeted proteomics investigation of the obesity paradox in venous thromboembolism.Blood advances · 2021Article
- Metabolic syndrome, neurohumoral modulation, and pulmonary arterial hypertension.British journal of pharmacology · 2020Review
- Pulmonary Hypertension and Obesity: Focus on Adiponectin.International journal of molecular sciences · 2019Review
- The role of adipokines as prognostic factors of one-year mortality in hip fracture patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Novel methods in pulmonary hypertension phenotyping in the age of precision medicine (2015 Grover Conference series).Pulmonary circulation · 2016Review
- Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice.International journal of clinical and experimental pathology · 2014Article
- Obesity, estrogens and adipose tissue dysfunction - implications for pulmonary arterial hypertension.Pulmonary circulationReview
- Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?Pulmonary circulationArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Evidence suggests that leptin is involved in relevant processes in the cardiovascular system. Low serum leptin levels have been associated with increased cardiovascular events and mortality in patients with coronary artery, diabetes, or chronic kidney disease. We hypothesized that leptin is increased in pulmonary arterial hypertension (PAH) and provides prognostic information. We correlated leptin levels with clinical data and assessed its association with survival. Sixty-seven patients with PAH and 29 healthy controls were studied. Plasma leptin levels were nonlinearly associated with BMI. Leptin level <15 μg/l was associated with higher mortality in PAH patients, with an adjusted (age, gender, BMI, and smoking status) hazard ratio of 3.8 (95% CI: 1.3-11.2), P=0.016. Similarly, PAH patients with leptin/BMI ratio <0.5 μg * m(2)/kg * l had worse survival than those with a level >0.5 μg * m(2)/ kg * l (P=0.046 by log-rank test). Two-year mortality in PAH patients was 24%. A receiver operating characteristic curve using leptin/BMI ratio as the test variable and 2-year mortality as the state variable showed an area under the curve of 0.74 (95% CI: 0.62-0.86). A leptin/BMI ratio cut-off of 0.6 had a high sensitivity (94%) and negative predictive value (96%) for predicting death of any cause at 2 years. In PAH, plasma leptin levels are directly associated with BMI. Lower leptin levels, when adjusted by BMI, are associated with an increased overall mortality and leptin/BMI ratio has high negative predictive value for mortality at 2 years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.