ArticlePulmonary circulation
Diagnosis and management of pulmonary hypertension associated with left ventricular diastolic dysfunction.
Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Impact of preoperative left ventricular diastolic dysfunction on primary graft dysfunction and mortality following lung transplantation.Journal of thoracic disease · 2025Article
- The Role of Imaging in Pulmonary Vascular Disease: The Clinician's Perspective.Radiologic clinics of North America · 2025Review
- Appreciation of Increased Pulmonary Vascular Resistance from the Maximum Desaturation in 2-Chair Test: An Appraisal.International journal of chronic obstructive pulmonary disease · 2025Article
- Article
- Pulmonary Hypertension in Interstitial Lung Disease: Updates in Disease, Diagnosis, and Therapeutics.Cells · 2023Review
- Four-dimensional flow cardiac magnetic resonance assessment of left ventricular diastolic function.Frontiers in cardiovascular medicine · 2022Review
- Cigarette Smoke Exposure and Radiographic Pulmonary Vascular Morphology in the Framingham Heart Study.Annals of the American Thoracic Society · 2019Article
- Right Ventricular Function Evaluated by Tricuspid Annular Plane Systolic Excursion Predicts Cardiovascular Death in the General Population.Journal of the American Heart Association · 2019Article
- Insights into the pulmonary vascular complications of heart failure with preserved ejection fraction.The Journal of physiology · 2019Review
- Independent predictors of developing pulmonary hypertension in heart failure with reduced versus preserved ejection fraction.Journal of the Saudi Heart Association · 2017Article
- Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2016Review
- Pulmonary artery to aorta ratio for the detection of pulmonary hypertension: cardiovascular magnetic resonance and invasive hemodynamics in heart failure with preserved ejection fraction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015Observational
- Pulmonary arterial hypertension: the clinical syndrome.Circulation research · 2014Review
- Provider recognition and response to echocardiographic findings indicating pulmonary hypertension in the Veterans affairs medical center population.Pulmonary circulation · 2013Article
- Pulmonary hypertension.European respiratory review : an official journal of the European Respiratory Society · 2013Review
- Vascular remodeling of the small pulmonary arteries and measures of vascular pruning on computed tomography.Pulmonary circulationArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary hypertension (PH) is commonly seen in patients who present with left ventricular diastolic dysfunction (LVDD) and is considered a marker of poor prognosis. While PH in this setting is thought to result from pulmonary venous congestion, there is a subset of patients in which pulmonary pressures fail to improve with appropriate management of diastolic heart failure and go on to develop a clinical picture similar to that of patients with pulmonary arterial hypertension (PAH). Despite the utility of Doppler echocardiography and exercise testing in the initial evaluation of patients with suspected PH-LVDD, the diagnosis can only be confirmed using right heart catheterization. Management of PH-LVDD centers on both optimizing fluid management and afterload reduction to reducing left ventricular diastolic pressures and also increase pulmonary venous return. To date, there is no clear evidence that addition of PH-specific drugs can improve clinical outcomes, and their use should only be considered in the setting of clinical trials. In conclusion, PH-LVDD remains a challenging clinical entity that complicates the management of left ventricular dysfunction and significantly contributes to its morbidity and mortality. Determination of the optimal diagnostic and treatment strategies for this form of PH should be the goal of future studies.
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