ArticleGynecological surgery2012
Seprafilm(®) adhesion barrier: (2) a review of the clinical literature on intraabdominal use.
Article in Gynecological surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Adhesion barriers in gynecologic surgeries and cesarean section: An Asia-Pacific expert panel consensus recommendation.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Pooled it
- Adhesion prevention agents for gynaecological surgery: an overview of Cochrane reviews.The Cochrane database of systematic reviews · 2015Pooled it
- Effectiveness and short-term safety of modified sodium hyaluronic acid-carboxymethylcellulose at cesarean delivery: a randomized trial.American journal of obstetrics and gynecology · 2016Trial
- Trial
- Pathophysiology, prevention and treatment of postoperative peritoneal adhesions: a WSES narrative.World journal of emergency surgery : WJES · 2026Review
- Cellular and molecular regulation of fibrotic postoperative abdominal adhesions.American journal of physiology. Cell physiology · 2026Review
- Sprayable Polymer Blends With Short-Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions.Advanced healthcare materials · 2026Article
- Hydrogels strategies for organ adhesions: from mechanism to application.Journal of nanobiotechnology · 2026Review
- Evaluation Starch-Based Hemostatic Agents "BioSight" as Adhesion Prevention Barrier Tested in an Adhesion Model in Rats.Polymers · 2025Article
- A Developmental Roadmap Toward Abdominal Adhesions Prevention Technologies.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Review
- Postoperative Adhesions: Current Research on Mechanisms, Therapeutics and Preventative Measures.Biomedical materials & devices (New York, N.Y.) · 2025Article
- Degradation Pattern of a Biodegradable and Photocurable Sealants Based on Hyaluronic Acid : A Serial Magnetic Resonance Imaging Observational Study in Rat Craniectomy Model.Journal of Korean Neurosurgical Society · 2025Article
- A Dual-Layer Hydrogel Barrier Integrating Bio-Adhesive and Anti-Adhesive Properties Prevents Postoperative Abdominal Adhesions.Advanced healthcare materials · 2025Article
- Physical and biological properties of a novel anti-adhesive punctate uneven gelatin film.PloS one · 2025Article
- Long-Term Efficacy and Safety of Adhesion Prevention Agents in Abdominal and Pelvic Surgeries: A Systematic Review.Cureus · 2024Review
- Global recommendations on adhesion prophylaxis in gynaecological laparoscopic surgery.Facts, views & vision in ObGyn · 2024Article
- Neutrophil Extracellular Traps: A Crucial Factor in Post-Surgical Abdominal Adhesion Formation.Cells · 2024Review
- Prediction of the minimum amount of anti-adhesive agent required for entire intra-abdominal cavity using fluorescent dye.Korean journal of clinical oncology · 2024Article
- Therapeutic adjuncts in the endoscopic management of urethral stricture disease: past, present, and future.Frontiers in urology · 2024Review
- Adhesive Small Bowel Obstruction: A Review.JNMA; journal of the Nepal Medical Association · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study seeks to provide a review of the clinical data published as of July 2011 concerning the postsurgical adhesion barrier, Seprafilm (chemically modified hyaluronic acid and carboxymethylcelulose; Genzyme Corporation, Cambridge, MA). Included articles detail the application of Seprafilm for intraabdominal uses that have been approved (on-label) and those considered investigational (off-label) by the FDA. Medline and EMBASE Drugs and Pharmaceuticals databases were searched for all original clinical Seprafilm research published as of July 2011. All human Seprafilm intraabdominal clinical reports and studies, excluding those related to prosthetic mesh were included. Data extraction involved the systematic review of each article. The data synthesis is the summary of Seprafilm human intraabdominal clinical reports and studies describing safety and/or efficacy. The safety and efficacy of Seprafilm in reducing postoperative adhesions has been clearly demonstrated in abdominal and pelvic laparotomy. While reports have described the safe and successful use of Seprafilm following laparoscopy, pediatric laparotomy, and in patients with malignancy and/or infection, the safety and efficacy of Seprafilm use in these procedures has not been definitively established in randomized controlled trials.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.