ArticleGynecological surgery2012
Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies.
Article in Gynecological surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Adhesion barriers in gynecologic surgeries and cesarean section: An Asia-Pacific expert panel consensus recommendation.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Pooled it
- Efficacy of hyaluronic acid and hydroxyethyl starch in preventing adhesion following endoscopic sinus surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Trial
- Prevention of adhesive small bowel obstruction by anti-adhesion barriers: do they really work?Techniques in coloproctology · 2026Review
- Sprayable Polymer Blends With Short-Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions.Advanced healthcare materials · 2026Article
- Hydrogel Microspheres for Biomedical Applications.Small science · 2026Review
- Evaluation of a Sprayable Hydrogel for Surgical Adhesion Prevention in Rat and Rabbit Models.Medical devices (Auckland, N.Z.) · 2026Article
- Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells.Journal of advanced research · 2025Article
- Postoperative Adhesions: Current Research on Mechanisms, Therapeutics and Preventative Measures.Biomedical materials & devices (New York, N.Y.) · 2025Article
- Gynecologic postoperative anti-adhesion barriers: From biomaterials to barrier development.Biomaterials and biosystems · 2025Review
- Advancements in the clinical management of adhesive small bowel obstruction: A perspective.Medicine · 2025Review
- Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering.Gels (Basel, Switzerland) · 2025Review
- Sporopollenin-based material for prevention of postoperative adhesions: a murine study.Annals of surgical treatment and research · 2025Article
- A Dual-Layer Hydrogel Barrier Integrating Bio-Adhesive and Anti-Adhesive Properties Prevents Postoperative Abdominal Adhesions.Advanced healthcare materials · 2025Article
- Physical and biological properties of a novel anti-adhesive punctate uneven gelatin film.PloS one · 2025Article
- A Scoping Review of Animal Models for Development of Abdominal Adhesion Prevention Strategies.The Journal of surgical research · 2024Article
- Prediction of the minimum amount of anti-adhesive agent required for entire intra-abdominal cavity using fluorescent dye.Korean journal of clinical oncology · 2024Article
- Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions.Bioengineering & translational medicine · 2023Review
- Injectable photocurable Janus hydrogel delivering hiPSC cardiomyocyte-derived exosome for post-heart surgery adhesion reduction.Science advances · 2023Article
- Postsurgical Adhesions: Is There Any Prophylactic Strategy Really Working?Journal of clinical medicine · 2023Review
- Sprayable tissue adhesive with biodegradation tuned for prevention of postoperative abdominal adhesions.Bioengineering & translational medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to provide a single site resource for investigators, clinicians, and others seeking preclinical, animal, and human investigational studies concerning the postsurgical, anti-adhesion barrier Seprafilm™ (Genzyme Corporation, Cambridge, MA). All published preclinical, animal, human extra-abdominal research as of July 2011 have been summarized and included in this document. Searches of Medline and EMBASE Drugs and Pharmaceuticals databases were conducted for original preclinical, animal, and human extra-abdominal studies involving Seprafilm. Preclinical, animal, and extra-abdominal human investigational studies are the study selection for this manuscript. Intraabdominal use is discussed in the accompanying manuscript. Data extraction includes systematic manuscript review. Summary of preclinical, animal, and extra-abdominal human investigational use of Seprafilm by surgical discipline were gathered for data synthesis. The clinical use of Seprafilm, which was approved by the FDA for intra-abdominal procedures, is supported by preclinical and animal studies relating to general surgical and obstetrical/gynecological applications. Findings from preclinical, animal, and human investigational studies at other sites throughout the body raises the potential for additional human clinical trials to assess efficacy and safety following surgical procedures at non-abdominal locations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.