ArticleInternational journal of molecular sciences2012
Genome-wide DNA methylation changes between the superficial and deep backfat tissues of the pig.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Transcriptomic profiling of backfat and muscle in Lijiang pigs with divergent body size across growth stages.Scientific reports · 2024Article
- Elucidating the Role of Transcriptomic Networks and DNA Methylation in Collagen Deposition of Dezhou Donkey Skin.Animals : an open access journal from MDPI · 2024Article
- Transgenerational epigenetic heritability for growth, body composition, and reproductive traits in Landrace pigs.Frontiers in genetics · 2024Article
- Promoter Methylation Changes inInternational journal of molecular sciences · 2022Article
- Article
- DNA methylation landscape of fat deposits and fatty acid composition in obese and lean pigs.Scientific reports · 2016Article
- Genome-wide analysis of DNA methylation in obese, lean, and miniature pig breeds.Scientific reports · 2016Article
- Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model.BMC genomics · 2015Article
- Genome-wide analysis of DNA methylation in pigs using reduced representation bisulfite sequencing.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adipose tissue is not only a storage organ involved in fuel metabolism, but also an endocrine organ involved in the regulation of insulin sensitivity, thermogenesis, immunity, and inflammation. There are anatomical, cellular, molecular and physiological differences among adipose tissues deposited in different body sites. However, current understanding of the intrinsic differences between the sub-compartments of the subcutaneous adipose tissue remains rudimentary. Here, we analyzed the genome-wide DNA methylation differences between the porcine superficial and deep backfat tissues using methylated DNA immunoprecipitation combined with high-throughput sequencing. We show that the genes with differentially methylated regions in their promoter are mainly involved in the processes of "lipid metabolism" and "regulation of immune-related cytokines". Compared with the deep backfat tissue, the promoters of genes related to the 'positive regulation of cytokine production' were significantly hypermethylated in the superficial backfat tissue, which reflects the intrinsic functional and metabolic differences between the sub-compartments of the subcutaneous adipose tissue. This study provides epigenetic evidence for functionally relevant methylation differences between different layers of porcine backfat tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.