ReviewInternational journal of molecular sciences2012
Mechanistic insights into neurotoxicity induced by anesthetics in the developing brain.
Review in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse.BMC medicine · 2025Article
- Ferroptosis is involved in regulating perioperative neurocognitive disorders: emerging perspectives.Journal of neuroinflammation · 2022Review
- Effect of Anesthetics on Functional Connectivity of Developing Brain.Frontiers in human neuroscience · 2022Review
- Influence of Previous General Anesthesia on Cognitive Impairment: An Observational Study Among 151 Patients.Frontiers in human neuroscience · 2022Article
- Early Isoflurane Exposure Impairs Synaptic Development in Fmr1 KO Mice via the mTOR Pathway.Neurochemical research · 2021Article
- Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment.Cell death discovery · 2021Article
- Propofol impairs specification of retinal cell types in zebrafish by inhibiting Zisp-mediated Noggin-1 palmitoylation and trafficking.Stem cell research & therapy · 2021Article
- Neuron-Glia Crosstalk Plays a Major Role in the Neurotoxic Effects of KetamineFrontiers in cell and developmental biology · 2021Article
- Free latissimus dorsi flap for upper extremity reconstruction in a 9-month-old.Case reports in plastic surgery & hand surgery · 2021Article
- Desoxyrhapontigenin attenuates neuronal apoptosis in an isoflurane-induced neuronal injury model by modulating the TLR-4/cyclin B1/Sirt-1 pathway.AMB Express · 2020Article
- Effects of Pregnancy Anesthesia on Fetal Nervous System.Frontiers in pharmacology · 2020Review
- Article
- Limb Remote Ischemic Preconditioning Reduces Repeated Ketamine Exposure-Induced Adverse Effects in the Developing Brain of Rats.Journal of molecular neuroscience : MN · 2019Article
- Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice.Scientific reports · 2018Article
- High-concentration sevoflurane exposure in mid-gestation induces apoptosis of neural stem cells in rat offspring.Neural regeneration research · 2018Article
- Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway.International journal of molecular sciences · 2018Article
- Sevoflurane Exacerbates Cognitive Impairment Induced by AMediators of inflammation · 2018Article
- Ferroptosis Contributes to Isoflurane Neurotoxicity.Frontiers in molecular neuroscience · 2018Article
- Upregulation of Cdh1 Attenuates Isoflurane-Induced Neuronal Apoptosis and Long-Term Cognitive Impairments in Developing Rats.Frontiers in cellular neuroscience · 2017Article
- Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children.Journal of neurosurgical anesthesiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compelling evidence has shown that exposure to anesthetics used in the clinic can cause neurodegeneration in the mammalian developing brain, but the basis of this is not clear. Neurotoxicity induced by exposure to anesthestics in early life involves neuroapoptosis and impairment of neurodevelopmental processes such as neurogenesis, synaptogenesis and immature glial development. These effects may subsequently contribute to behavior abnormalities in later life. In this paper, we reviewed the possible mechanisms of anesthetic-induced neurotoxicity based on new in vitro and in vivo findings. Also, we discussed ways to protect against anesthetic-induced neurotoxicity and their implications for exploring cellular and molecular mechanisms of neuroprotection. These findings help in improving our understanding of developmental neurotoxicology and in avoiding adverse neurological outcomes in anesthesia practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.