ArticleBreast cancer : basic and clinical research2012
Insulin-like growth factor 1 gene polymorphism and breast cancer risk among arab omani women: a case-control study.
Article in Breast cancer : basic and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 10 citations in OpenAlex.
- Breast Cancer in the Arabian Gulf Countries.Cancers · 2023Review
- The effects of genetic variants related to insulin metabolism pathways and the interactions with lifestyles on colorectal cancer risk.Menopause (New York, N.Y.) · 2019Observational
- Genetic Variants in Metabolic Signaling Pathways and Their Interaction with Lifestyle Factors on Breast Cancer Risk: A Random Survival Forest Analysis.Cancer prevention research (Philadelphia, Pa.) · 2018Article
- Article
- The role of the insulin-like growth factor-1 system in breast cancer.Molecular cancer · 2015Review
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
unlabelledBreast cancer is the most common cancer worldwide with significant global burden. Insulin-like growth factor 1 (IGF1) is an important regulator of cellular growth, differentiation, and apoptosis and mitogenic and antiapoptotic activities. Some studies suggested an association between cytosine adenine (CA) repeats gene polymorphisms of IGF1 and the risk of developing breast cancer while other studies did not find such an association. This study aims investigate the role of IGF1 (CA) repeats gene polymorphisms in the risk of developing breast cancer among Omani women.
methodsWe analyzed (CA) repeats gene polymorphisms of IGF1 by extraction of genomic DNA from the peripheral blood of 147 patients with breast cancer and 134 control participants and performed genotyping using DNA sequencing.
resultsApproximately 46% of patients carried the IGF (CA)(19) repeat allele, with 31.3% carrying two copies of this allele and 50% of controls carried the IGF (CA)(19) repeat allele with 30.1% carrying two copies of this allele. The difference of the IGF CA repeat groups was significant between cases and controls with (P =0.02). In contrast, there was no difference in the distribution of (CA)(19) repeat allele, (CA)(18) repeat allele and (CA)(19) repeat allele between cases and controls. The difference of the CA groups was significant between cases and controls among postmenopausal women with (P =0.026), whereas no difference was observed among postmenopausal subjects (P =0.429). In both pre- and postmenopausal groups there was no difference in the distribution of (CA)(19) repeat allele, (CA)(18) repeat allele and (CA)(20) repeat allele between patients and control subjects. On further IGF1 genotypes classification, we found an association between progesterone receptor status and the genotypes group where the non carrier of (CA)(19) repeat group was compared to (CA)(19) repeat carrier group (OR =2.482; 95% CI =1.119-5.503; P value =0.023).
conclusionOverall there was no association between the IGF (CA)(19) repeat and breast cancer in Omani females.
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