Evidence map›Paper›PMID 22837515›Full record

ArticleScience (New York, N.Y.)2012

Molecular biology. Use and abuse of RNAi to study mammalian gene function.

William G Kaelin

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed.

  1. Article
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  4. Review
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  11. Article
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  14. A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  15. CRISPR Screens to Identify Regulators of Tumor Immunity.Annual review of cancer biology · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

William G KaelinDepartment of Adult Oncology, Office M457, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. william_kaelin@dfci.harvard.edu

Funding

The von Hippel-Lindau Tumor Suppressor Protein:Roles in Cancer and Oxygen SensingR01CA068490 · NCI · DANA-FARBER CANCER INSTITUTE · PI KAELIN, WILLIAM G. · 1996 to 2015
$4.8M
The RBP2/JARID1A/KDM5A Histone Demethylase as a Potential Drug Target in CancerR01CA076120 · NCI · DANA-FARBER CANCER INSTITUTE · PI KAELIN, WILLIAM G. · 1998 to 2015
$3.6M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA068490NCI NIH HHS R01 CA076120
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Knockdown TechniquesRNA InterferenceAlgorithmsAnimalsGenesGene TargetingHigh-Throughput Screening AssaysHumansMammalsPhenotypeRNA, Small InterferingRNA, Small Interfering

Identifiers

PMID22837515
PMCPMC3705935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.