ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation.eLife · 2025Article
- The Spleen Modulates the Balance of Natural and Pathological Autoantibodies in a Mouse Model of Autoimmune Arthritis.International journal of molecular sciences · 2024Article
- Microbiota and B-1 B cell repertoire development in mice.Current opinion in immunology · 2024Review
- Antifungal antibodies present in intravenous immunoglobulin derived from China.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development.Immunity · 2020Article
- Glycan Reactive Natural Antibodies and Viral Immunity.Viral immunology · 2020Review
- Immunoglobulin M in Health and Diseases: How Far Have We Come and What Next?Frontiers in immunology · 2020Review
- The immunology of the allergy epidemic and the hygiene hypothesis.Nature immunology · 2017Review
- CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Immunological Outcomes of Antibody Binding to Glycans Shared between Microorganisms and Mammals.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Pulmonary α-1,3-Glucan-Specific IgA-Secreting B Cells Suppress the Development of Cockroach Allergy.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- Manipulation of the glycan-specific natural antibody repertoire for immunotherapy.Immunological reviews · 2016Review
- B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production.Frontiers in immunology · 2016Review
- Neonatal exposure to pneumococcal phosphorylcholine modulates the development of house dust mite allergy during adult life.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Antibodies generated against Streptococci protect in a mouse model of disseminated aspergillosis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Fungal disease of the nose and sinuses: an updated overview.Current allergy and asthma reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There has been a sharp rise in allergic asthma and asthma-related deaths in the developed world, in contrast to many childhood illnesses that have been reduced or eliminated. The hygiene hypothesis proposes that excessively sanitary conditions early in life result in autoimmune and allergic phenomena because of a failure of the immune system to receive proper microbial stimulation during development. We demonstrate that Abs generated against conserved bacterial polysaccharides are reactive with and dampen the immune response against chitin and Aspergillus fumigatus. A reduction in Ag uptake, cell influx, cell activation, and cytokine production occurred in the presence of anti-polysaccharide Abs, resulting in a striking decrease in the severity of allergic airway disease in mice. Overall, our results suggest that Ag exposure--derived from environmental sources, self-antigens, or vaccination--during the neonatal period has dramatic effects on the adult Ab response and modifies the development of allergic airway disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.