ArticleBiology of reproduction2012
Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.
Article in Biology of reproduction, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Post-Translational Modifications of Tubulin in Oocyte Maturation and Female Infertility.Cytoskeleton (Hoboken, N.J.) · 2026Review
- Interplay of aurora kinase a functional residues and Epstein-barr Nuclear Antigen 1 in Epstein-barr virus associated Gastric cancer using AGS cells.BMC cancer · 2025Article
- Spatio-temporal requirements of Aurora kinase A in mouse oocyte meiotic spindle building.iScience · 2024Article
- Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis.Cell communication and signaling : CCS · 2024Article
- Genetic interaction mapping of Aurora protein kinases in mouse oocytes.Frontiers in cell and developmental biology · 2024Article
- Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality.Advances in anatomy, embryology, and cell biology · 2024Review
- Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.EMBO reports · 2023Article
- Predicting embryonic aneuploidy rate in IVF patients using whole-exome sequencing.Human genetics · 2022Article
- Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction†.Biology of reproduction · 2022Review
- Microtubule organizing centers regulate spindle positioning in mouse oocytes.Developmental cell · 2022Article
- Loss of acentriolar MTOCs disrupts spindle pole Aurora A and assembly of the liquid-like meiotic spindle domain in oocytes.Journal of cell science · 2021Article
- Single human oocyte transcriptome analysis reveals distinct maturation stage-dependent pathways impacted by age.Aging cell · 2021Article
- Aurora kinase A is essential for meiosis in mouse oocytes.PLoS genetics · 2021Article
- Mechanisms underlying disruption of oocyte spindle stability by bisphenol compounds.Reproduction (Cambridge, England) · 2020Article
- CEP215 and AURKA regulate spindle pole focusing and aMTOC organization in mouse oocytes.Reproduction (Cambridge, England) · 2020Article
- RanGTP and importin β regulate meiosis I spindle assembly and function in mouse oocytes.The EMBO journal · 2020Article
- Article
- A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.Science (New York, N.Y.) · 2019Article
- Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression.Journal of animal science and biotechnology · 2019Article
- Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes.The Journal of cell biology · 2017Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Aurora kinase A (AURKA) is an important mitotic kinase involved in the G2/M transition, centrosome maturation and separation, and spindle formation in somatic cells. We used transgenic models that specifically overexpress in mouse oocytes either wild-type (WT-AURKA) or a catalytically inactive (kinase-dead) (KD-AURKA) AURKA to gain new insights regarding the role of AURKA during oocyte maturation. AURKA activation occurs shortly after hCG administration that initiates maturation in vivo. Although AURKA activity is increased in WT-AURKA oocytes, resumption of meiosis is not observed in the absence of hCG administration. Control oocytes contain one to three microtubule organizing centers (MTOCs; centrosome equivalent) at prophase I. At the time of germinal vesicle breakdown (GVBD), the first visible marker of resumption of meiosis, the MTOC number increases. In WT-AURKA oocytes, the increase in MTOC number occurs prematurely but transiently without GVBD, whereas the increase in MTOC number does not occur in control and KD-AURKA oocytes. AURKA activation is biphasic with the initial activation not requiring CDC25B-CDK1 activity, whereas full activation, which is essential for the increase in MTOCs number, depends on CDK1 activity. AURKA activity also influences spindle length and regulates, independent of its protein kinase activity, the amount of MTOC associated with gamma-tubulin. Both WT-AURKA and KD-AURKA transgenic mice have normal fertility during first 6 mo of life. These results suggest that although AURKA is not a trigger kinase for G2/M transition in mouse oocytes, it regulates MTOC number and spindle length, and, independent of its protein kinase activity, gamma-tubulin recruitment to MTOCs.
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