Evidence map›Paper›PMID 22837464›Full record

ArticleThe Journal of experimental biology2012

Encephalic photoreception and phototactic response in the troglobiont Somalian blind cavefish Phreatichthys andruzzii.

Emma E Tarttelin, Elena Frigato, James Bellingham, Viviana Di Rosa, Roberto Berti, Nicholas S Foulkes, Robert J Lucas, Cristiano Bertolucci

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Eyeless cave-dwellingScience advances · 2023
    Article
  6. Article
  7. Article
  8. An Overview of Monthly Rhythms and Clocks.Frontiers in neurology · 2017
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Emma E TarttelinFaculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Elena Frigato
James Bellingham
Viviana Di Rosa
Roberto Berti
Nicholas S Foulkes
Robert J Lucas
Cristiano Bertolucci
University of Ferrara · ITUniversity of Manchester · GBKarlsruhe Institute of Technology · DEUniversity of Florence · IT

Funding

Wellcome TrustWellcome Trust WT078808
6 · The paper itself

Abstract

Many physiological and behavioural responses to changes in environmental lighting conditions are mediated by extraocular photoreceptors. Here we investigate encephalic photoreception in Phreatichthys andruzzii, a typical cave-dwelling fish showing an extreme phenotype with complete anophthalmy and a reduction in size of associated brain structures. We firstly identified two P. andruzzii photopigments, orthologues of rod opsin and exo-rod opsin. In vitro, both opsins serve as light-absorbing photopigments with λ(max) around 500 nm when reconstituted with an A(1) chromophore. When corrected for the summed absorption from the skin and skull, the spectral sensitivity profiles shifted to longer wavelengths (rod opsin: 521 nm; exo-rod opsin: 520 nm). We next explored the involvement of both opsins in the negative phototaxis reported for this species. A comparison of the spectral sensitivity of the photophobic response with the putative A(2) absorbance spectra corrected for skin/skull absorbance indicates that the A(2) versions of either or both of these pigments could explain the observed behavioural spectral sensitivity.

Indexed as

AbsorptionAmino Acid SequenceAnimalsBlindnessBrainCavesCypriniformesHEK293 CellsHumansLight Signal TransductionMolecular Sequence DataPhotobleachingPhotoreceptor Cells, VertebrateRod OpsinsSequence AlignmentSomaliaRod Opsins

Identifiers

PMID22837464
PMCPMC3404804
OpenAlexW2101084920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.