ArticleJournal of clinical microbiology2012
Modeling uncertainty in single-copy assays for HIV.
Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Modelling HIV-1 2-LTR dynamics following raltegravir intensification.Journal of the Royal Society, Interface · 2013Trial
- More than a drop of blood: the paradigm shift of a large-volume capillary sample for point-of-care clinical diagnostics.Journal of clinical microbiology · 2026Review
- Enhanced detection of low-level viremia by cobas 5800/6800 testing systems: a multi-center evaluation and clinical calibration study in China.Frontiers in cellular and infection microbiology · 2026Article
- Modeling HIV-1 Within-Host Dynamics After Passive Infusion of the Broadly Neutralizing Antibody VRC01.Frontiers in immunology · 2021Article
- Optimal control modulation of HIV reservoir formation rate by antigen infusion.Proceedings of the ... IEEE Conference on Decision & Control. IEEE Conference on Decision & Control · 2019Article
- HIV 2-LTR experiment design optimization.PloS one · 2018Article
- Implications of Measurement Assay Type in Design of HIV Experiments.Proceedings of the ... IEEE Conference on Decision & Control. IEEE Conference on Decision & Control · 2017Article
- Experiment Design for Early Molecular Events in HIV Infection.Proceedings of the ... American Control Conference. American Control Conference · 2017Article
- Order preservation of expected information content using Unscented Transform approximation of multivariate prior distributions in HIV 2-LTR experiment design.Proceedings of the ... IEEE Conference on Decision & Control. IEEE Conference on Decision & Control · 2016Article
- Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells.Journal of virology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We present a simple computational model of measurement accuracy for single-copy sensitivity assays (SCA) of HIV RNA that was developed from first principles. The model shows that the SCA is significantly right-skewed. Measured virus concentrations of 1 and 10 virions/ml had overlapping 95% confidence intervals and were statistically indistinguishable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.