Evidence map›Paper›PMID 22837285›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2012

Office-based elastographic technique for quantifying mechanical properties of skeletal muscle.

Jeffrey J Ballyns, Diego Turo, Paul Otto, Jay P Shah, Jennifer Hammond, Tadesse Gebreab, Lynn H Gerber, Siddhartha Sikdar

3 registry-linked trialsOpen access · greenAbstract readValidation Study
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03689283 nacompletednot on this mapstarted 2018, after this paper: background citation

The Effect of Dry Needling on Muscle Stiffness, Gait, Motion, and Strength in Healthy Individuals With Latent Trigger Points

TypeinterventionalSponsorRegis UniversityRan2018 to 2020Enrolled102ConditionsTrigger Point Pain, MyofascialArmsDry Needling, Sham Dry Needlling
NCT04758065 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Effectiveness of the Application of Radial Pressure Waves Together With a Manual Therapy Protocol and Therapeutic Exercise in the Treatment of Non-Specific Neck Pain: a Randomized Clinical Trial

TypeinterventionalSponsorUniversidad Pontificia ComillasRan2021 to 2025Enrolled60ConditionsNeck PainArmsRadial pressure waves Therapy, Therapeutic Exercise and Manual Therapy
NCT06060925 completednot on this mapstarted 2023, after this paper: background citation

Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain

TypeobservationalSponsorGeorge Mason UniversityRan2023 to 2025Enrolled96ConditionsMyofascial Pain Syndrome, HealthyArmsUltrasound imaging, Bioimpedance spectroscopy, Electromyography, Physical examination
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  3. Assessment of Myofascial Trigger Points via Imaging: A Systematic Review.American journal of physical medicine & rehabilitation · 2021
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Novel Use of Ultrasound Elastography to Quantify Muscle Tissue Changes After Dry Needling of Myofascial Trigger Points in Patients With Chronic Myofascial Pain.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2015
    Trial
  8. Article
  9. Article
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  11. Exploring fascia in myofascial pain syndrome: an integrative model of mechanisms.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Trigger Point Injections.Physical medicine and rehabilitation clinics of North America · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jeffrey J BallynsDepartment of Electrical and Computer Engineering, George Mason University, Fairfax, Virginia 22030, USA.
Diego Turo
Paul Otto
Jay P Shah
Jennifer Hammond
Tadesse Gebreab
Lynn H Gerber
Siddhartha Sikdar
George Mason University · USNational Institutes of Health · US

Funding

Pathogenesis and Pathophysiological Mechanisms of Myofascial Trigger PointsR01AR057348 · NIAMS · GEORGE MASON UNIVERSITY · PI SIKDAR, SIDDHARTHA · 2010 to 2013
$1.8M
Comparison of the Local Tissue Milieu in Normal muscle and Active and Latent MyoZIACL060060 · CLC · CLINICAL CENTER · PI SHAH, JAY · 2009 to 2012
$0k
NIAMS NIH HHS 1R01-AR057348NIAMS NIH HHS R01 AR057348
6 · The paper itself

Abstract

objectivesOur objectives were to develop a new, efficient, and easy-to-administer approach to ultrasound elastography and assess its ability to provide quantitative characterization of viscoelastic properties of skeletal muscle in an outpatient clinical environment. We sought to show its validity and clinical utility in assessing myofascial trigger points, which are associated with myofascial pain syndrome.

methodsUltrasound imaging was performed while the muscle was externally vibrated at frequencies in the range of 60 to 200 Hz using a handheld vibrator. The spatial gradient of the vibration phase yielded the shear wave speed, which is related to the viscoelastic properties of tissue. The method was validated using a calibrated experimental phantom, the biceps brachii muscle in healthy volunteers (n = 6), and the upper trapezius muscle in symptomatic patients with axial neck pain (n = 13) and asymptomatic (pain-free) control participants (n = 9).

resultsUsing the experimental phantom, our method was able to quantitatively measure the shear moduli with error rates of less than 20%. The mean shear modulus ± SD in the normal biceps brachii measured 12.5 ± 3.4 kPa, within the range of published values using more sophisticated methods. Shear wave speeds in active myofascial trigger points and the surrounding muscle tissue were significantly higher than those in normal tissue at high frequency excitations (>100 Hz; P < .05).

conclusionsOff-the-shelf office-based equipment can be used to quantitatively characterize skeletal muscle viscoelastic properties with estimates comparable to those using more sophisticated methods. Our preliminary results using this method indicate that patients with spontaneous neck pain and symptomatic myofascial trigger points have increased tissue heterogeneity at the trigger point site and the surrounding muscle tissue.

Indexed as

AdultAnalysis of VarianceCase-Control StudiesElasticity Imaging TechniquesFemaleHumansMaleMuscle, SkeletalMyofascial Pain SyndromesPhantoms, ImagingPhysical ExaminationSignal Processing, Computer-Assisted

Identifiers

PMID22837285
PMCPMC3493148
OpenAlexW1841582598

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.