ArticleInvestigative ophthalmology & visual science2012
Wavelength-dependent change of retinal nerve fiber layer reflectance in glaucomatous retinas.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Increase of retinal layer thickness in a rat model of acute intraocular hypertension.Experimental eye research · 2026Article
- Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma.Journal of clinical medicine · 2024Review
- Visible Light Optical Coherence Tomography of Peripapillary Retinal Nerve Fiber Layer Reflectivity in Glaucoma.Translational vision science & technology · 2022Article
- Reflectance evaluation of eye fundus structures with a visible and near-infrared multispectral camera.Biomedical optics express · 2022Article
- Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model.Neurophotonics · 2019Article
- Temporal change of retinal nerve fiber layer reflectance speckle in normal and hypertensive retinas.Experimental eye research · 2019Article
- Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina.Biomedical optics express · 2018Article
- White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina.Biomedical optics express · 2018Article
- Response of the Retinal Nerve Fiber Layer Reflectance and Thickness to Optic Nerve Crush.Investigative ophthalmology & visual science · 2018Article
- Biological aspects of axonal damage in glaucoma: A brief review.Experimental eye research · 2017Review
- Reflectance Spectrum and Birefringence of the Retinal Nerve Fiber Layer With Hypertensive Damage of Axonal Cytoskeleton.Investigative ophthalmology & visual science · 2017Article
- Optical Detection of Early Damage in Retinal Ganglion Cells in a Mouse Model of Partial Optic Nerve Crush Injury.Investigative ophthalmology & visual science · 2016Article
- Investigating Tissue Optical Properties and Texture Descriptors of the Retina in Patients with Multiple Sclerosis.PloS one · 2015Article
- The path to clinical translation for visible light optical coherence tomography in retinal imaging.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeRetinal nerve fiber layer (RNFL) reflectance is often used in optical methods for RNFL assessment in clinical diagnosis of glaucoma, yet little is known about the reflectance property of the RNFL under the development of glaucoma. This study measured the changes in RNFL reflectance spectra that occurred in retinal nerve fiber bundles with different degrees of glaucomatous damage.
methodsA rat model of glaucoma with laser photocoagulation of trabecular meshwork was used. Reflectance of the RNFL in an isolated retina was measured at wavelengths of 400-830 nm. Cytostructural distribution of the bundles measured optically was evaluated by confocal imaging of immunohistochemistry staining of cytoskeletal components, F-actin, microtubules, and neurofilaments. RNFL reflectance spectra were studied in bundles with normal-looking appearance, early F-actin distortion, and apparent damage of all cytoskeletal components. Changes of RNFL reflectance spectra were studied at different radii (0.22, 0.33, and 0.44 mm) from the optic nerve head (ONH).
resultsBundles in 30 control retinas and 41 glaucomatous retinas were examined. In normal retinas, reflectance spectra were similar along the same bundles. In glaucomatous retinas, reflectance spectra changed along bundles with the spectra becoming flatter as bundle areas approached the ONH.
conclusionsElevation of intraocular pressure (IOP) causes nonuniform changes in RNFL reflectance across wavelengths. Changes of reflectance spectra occur early in bundles near the ONH and prior to apparent cytoskeletal distortion. Using the ratio of RNFL reflectance measured at different wavelengths can provide early and sensitive detection of glaucomatous damage.
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