ReviewCurrent neurology and neuroscience reports2012
Therapeutic hypothermia for traumatic brain injury.
Review in Current neurology and neuroscience reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Neuroprotection strategies in traumatic brain injury: Studying the effectiveness of different clinical approaches.Surgical neurology international · 2024Review
- Diclofenac Sodium for Fever Control in Neurocritical Care: A Systematic Review.Journal of clinical medicine · 2023Review
- Selective head cooling in the acute phase of concussive injury: a neuroimaging study.Frontiers in neurology · 2023Article
- A 3-D virtual human model for simulating heat and cold stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Ten Rules for the Management of Moderate and Severe Traumatic Brain Injury During Pregnancy: An Expert Viewpoint.Frontiers in neurology · 2022Review
- Preventive effects of seat belts on traumatic brain injury in motor vehicle collisions classified by crash severities and collision directions.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Selective head-neck cooling after concussion shortens return-to-play in ice hockey players.Concussion (London, England) · 2021Article
- Article
- iTRAQ-Based Quantitative Proteomics Reveals the New Evidence Base for Traumatic Brain Injury Treated with Targeted Temperature Management.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Article
- Preventive Effects of Safety Helmets on Traumatic Brain Injury after Work-Related Falls.International journal of environmental research and public health · 2016Observational
- Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat.Scientific reports · 2016Article
- Moderate Hypothermia Significantly Decreases Hippocampal Cell Death Involving Autophagy Pathway after Moderate Traumatic Brain Injury.Journal of neurotrauma · 2015Article
- Effects of methylprednisolone on neuroprotective effects of delay hypothermia on spinal cord injury in rat.Asian spine journal · 2015Article
- Specific intensive care management of patients with traumatic brain injury: Present and future.Saudi journal of anaesthesia · 2014Review
- Therapeutic Hypothermia in Children and Adults with Severe Traumatic Brain Injury.Therapeutic hypothermia and temperature management · 2014Review
- The pathophysiological mechanisms of the onset of death through accidental hypothermia and the presentation of "The little match girl" case.Clujul medical (1957) · 2014Article
- Fundamental research progress of mild hypothermia in cerebral protection.SpringerPlus · 2013Article
- Effects of Mild Hypothermia Treatment on Rat Hippocampal β-Amyloid Expression Following Traumatic Brain Injury.Therapeutic hypothermia and temperature management · 2013Article
- Neurotrauma and Repair Research: Traumatic Brain Injury (TBI) and its Treatments.Biomedical engineering and computational biology · 2013Review
- Therapeutic hypothermia brings favorable neurologic outcomes in children with near drowning.Tzu chi medical journalArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental evidence demonstrates that therapeutic temperature modulation with the use of mild induced hypothermia (MIH, defined as the maintenance of body temperature at 32-35 °C) exerts significant neuroprotection and attenuates secondary cerebral insults after traumatic brain injury (TBI). In adult TBI patients, MIH has been used during the acute "early" phase as prophylactic neuroprotectant and in the sub-acute "late" phase to control brain edema. When used to control brain edema, MIH is effective in reducing elevated intracranial pressure (ICP), and is a valid therapy of refractory intracranial hypertension in TBI patients. Based on the available evidence, we recommend: applying standardized algorithms for the management of induced cooling; paying attention to limit potential side effects (shivering, infections, electrolyte disorders, arrhythmias, reduced cardiac output); and using controlled, slow (0.1-0.2 °C/h) rewarming, to avoid rebound ICP. The optimal temperature target should be titrated to maintain ICP <20 mmHg and to avoid temperatures <35 °C. The duration of cooling should be individualized until the resolution of brain edema, and may be longer than 48 h. Patients with refractory elevated ICP following focal TBI (e.g. hemorrhagic contusions) may respond better to MIH than those with diffuse injury. Randomized controlled trials are underway to evaluate the impact of MIH on neurological outcome in adult TBI patients with elevated ICP. The use of MIH as prophylactic neuroprotectant in the early phase of adult TBI is not supported by clinical evidence and is not recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.