ArticleJournal of abnormal child psychology2013
5-HTTLPR X stress in adolescent depression: moderation by MAOA and gender.
Article in Journal of abnormal child psychology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Role of polygenic risk scores in the association between chronotype and health risk behaviors.BMC psychiatry · 2023Article
- Biomarkers in Child and Adolescent Depression.Child psychiatry and human development · 2023Review
- Intersection of Sex and Depression: Pathogenesis, Presentation, and Treatments.Handbook of experimental pharmacology · 2023Article
- The Role of Sex in Genetic Association Studies of Depression.Journal of psychiatry and brain science · 2022Article
- Serotonergic influence on depressive symptoms and trait anxiety is mediated by negative life events and frontal activation in children and adolescents.European child & adolescent psychiatry · 2020Article
- The MAOA Gene Influences the Neural Response to Psychosocial Stress in the Human Brain.Frontiers in behavioral neuroscience · 2020Article
- Gender Differences in Depression: Evidence From Genetics.Frontiers in genetics · 2020Review
- Brain monoamine oxidase A in seasonal affective disorder and treatment with bright light therapy.Translational psychiatry · 2018Article
- Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders.Journal of neuroscience research · 2017Review
- MAOA Influences the Trajectory of Attentional Development.Frontiers in human neuroscience · 2016Article
- Depression from childhood into late adolescence: Influence of gender, development, genetic susceptibility, and peer stress.Journal of abnormal psychology · 2015Article
- Serotonin transporter gene polymorphism (5-HTTLPR) L allele interacts with stress to increase anxiety symptoms in Chinese adolescents: a multiwave longitudinal study.BMC psychiatry · 2015Article
- Polygenic risk, stressful life events and depressive symptoms in older adults: a polygenic score analysis.Psychological medicine · 2015Article
- The Involvement of Genes in Adolescent Depression: A Systematic Review.Frontiers in behavioral neuroscience · 2015Review
- Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology.Drug and alcohol dependence · 2014Article
- The role of the monoamine oxidase A gene in moderating the response to adversity and associated antisocial behavior: a review.Psychology research and behavior management · 2014Review
- Interaction between a serotonin transporter gene promoter region polymorphism and stress predicts depressive symptoms in Chinese adolescents: a multi-wave longitudinal study.BMC psychiatry · 2013Article
- Epigenetic Modulation of Mood Disorders.Journal of genetic syndromes & gene therapy · 2013Article
- Role of 5-HTTLPR polymorphism in the development of the inward/outward personality organization: a genetic association study.PloS one · 2013Article
- Health Disparities by Sexual Orientation: Implications of Genetic and Environmental Explanations.Journal of sex researchArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Depression surges in adolescence, especially among girls. Most evidence indicates that the short allele of a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) interacts with stress to influence the onset of depression. This effect appears to be less robust in adolescents, particularly among boys, and may be moderated by other genetic polymorphisms. Seeking to explain the adolescent gender difference in depression, this study examined the effects of 5-HTTLPR (rs25531), the monoamine oxidase A-upstream variable number tandem repeat (MAOA-uVNTR), and negative life events (NLE). A community-based longitudinal sample of 309 adolescents reported depressive symptoms and NLE at ages 11, 13, and 15. 5-HTTLPR and MAOA-uVNTR genotypes were ascertained via buccal swabs. A significant four-way interaction of 5-HTTLPR, MAOA-uVNTR, NLE at age 13, and gender predicted depressive symptoms at age 15. Girls were most likely to exhibit elevated depressive symptoms when experiencing NLE if they possessed low-expression MAOA-uVNTR alleles and short 5-HTTLPR alleles, whereas low-expression MAOA-uVNTR alleles but long 5-HTTLPR alleles were implicated in boys. The results indicate that the commonly reported 5-HTTLPR by stress interaction for depression may be limited to individuals with low-expression MAOA-uVNTR alleles. These data also provide new evidence that the short allele of 5-HTTLPR confers susceptibility to stress differently for females compared with males.
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