ArticleEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2012
Laser-engineered dissolving microneedles for active transdermal delivery of nadroparin calcium.
Article in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- A comprehensive review of thermal ablation technologies for transdermal drug delivery: mechanisms, commercial products, and future smart systems.Drug delivery and translational research · 2026Review
- Dissolving and Swelling Hydrogel-Based Microneedles: An Overview of Their Materials, Fabrication, Characterization Methods, and Challenges.Gels (Basel, Switzerland) · 2023Review
- How physical techniques improve the transdermal permeation of therapeutics: A review.Medicine · 2022Review
- Finite Element Analysis for Biodegradable Dissolving Microneedle Materials on Skin Puncture and Mechanical Performance Evaluation.Polymers · 2021Article
- Transdermal Delivery of Salmon Calcitonin Using a Dissolving Microneedle Array: Characterization, Stability, and In vivo Pharmacodynamics.AAPS PharmSciTech · 2020Article
- Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2020Article
- Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases.Nutrients · 2020Review
- Design and Development of Liquid Drug Reservoirs for Microneedle Delivery of Poorly Soluble Drug Molecules.Pharmaceutics · 2019Article
- Fabrication of Circular Obelisk-Type Multilayer Microneedles Using Micro-Milling and Spray Deposition.Frontiers in bioengineering and biotechnology · 2018Article
- Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Dissolving Microneedle Patches for Dermal Vaccination.Pharmaceutical research · 2017Review
- Microneedles with Controlled Bubble Sizes and Drug Distributions for Efficient Transdermal Drug Delivery.Scientific reports · 2016Article
- Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery.Drug delivery and translational research · 2016Article
- Microneedles: A New Frontier in Nanomedicine Delivery.Pharmaceutical research · 2016Review
- Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum.Pharmaceutics · 2015Review
- Laser-engineered dissolving microneedle arrays for protein delivery: potential for enhanced intradermal vaccination.The Journal of pharmacy and pharmacology · 2015Article
- Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- Microneedle/nanoencapsulation-mediated transdermal delivery: mechanistic insights.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2014Article
- Microneedles for intradermal and transdermal drug delivery.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2013Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
There is an urgent need to replace the injection currently used for low molecular weight heparin (LMWH) multidose therapy with a non- or minimally invasive delivery approach. In this study, laser-engineered dissolving microneedle (DMN) arrays fabricated from aqueous blends of 15% w/w poly(methylvinylether-co-maleic anhydride) were used for the first time in active transdermal delivery of the LMWH nadroparin calcium (NC). Importantly, an array loading of 630IU of NC was achieved without compromising the array mechanical strength or drug bioactivity. Application of NC-DMNs to dermatomed human skin (DHS) using the single-step 'poke and release' approach allowed permeation of approximately 10.6% of the total NC load over a 48-h study period. The cumulative amount of NC that permeated DHS at 24h and 48h attained 12.28±4.23IU/cm(2) and 164.84±8.47IU/cm(2), respectively. Skin permeation of NC could be modulated by controlling the DMN array variables, such as MN length and array density as well as application force to meet various clinical requirements including adjustment for body mass and renal function. NC-loaded DMN offers great potential as a relatively low-cost functional delivery system for enhanced transdermal delivery of LMWH and other macromolecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.