Evidence map›Paper›PMID 22835925›Full record

SynthesisBMJ (Clinical research ed.)2012

Shift work and vascular events: systematic review and meta-analysis.

Manav V Vyas, Amit X Garg, Arthur V Iansavichus, John Costella, Allan Donner, Lars E Laugsand, Imre Janszky, Marko Mrkobrada, Grace Parraga, Daniel G Hackam

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 370 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
370citing papers in PubMed, 10 pooled it
39.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

370 citing papers in PubMed, 10 syntheses or guidelines pooled it, 822 citations in OpenAlex.

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  7. Shift Work and Early Arterial Stiffness: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  9. Shift work and health outcomes: an umbrella review of systematic reviews and meta-analyses of epidemiological studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
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310 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Manav V VyasDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Amit X Garg
Arthur V Iansavichus
John Costella
Allan Donner
Lars E Laugsand
Imre Janszky
Marko Mrkobrada
Grace Parraga
Daniel G Hackam
Western University · CANorwegian University of Science and Technology · NOLawson Health Research Institute · CARobarts Clinical Trials · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

objectiveTo synthesise the association of shift work with major vascular events as reported in the literature. DATA SOURCES: Systematic searches of major bibliographic databases, contact with experts in the field, and review of reference lists of primary articles, review papers, and guidelines. STUDY SELECTION: Observational studies that reported risk ratios for vascular morbidity, vascular mortality, or all cause mortality in relation to shift work were included; control groups could be non-shift ("day") workers or the general population. DATA EXTRACTION: Study quality was assessed with the Downs and Black scale for observational studies. The three primary outcomes were myocardial infarction, ischaemic stroke, and any coronary event. Heterogeneity was measured with the I(2) statistic and computed random effects models.

results34 studies in 2,011,935 people were identified. Shift work was associated with myocardial infarction (risk ratio 1.23, 95% confidence interval 1.15 to 1.31; I(2)=0) and ischaemic stroke (1.05, 1.01 to 1.09; I(2)=0). Coronary events were also increased (risk ratio 1.24, 1.10 to 1.39), albeit with significant heterogeneity across studies (I(2)=85%). Pooled risk ratios were significant for both unadjusted analyses and analyses adjusted for risk factors. All shift work schedules with the exception of evening shifts were associated with a statistically higher risk of coronary events. Shift work was not associated with increased rates of mortality (whether vascular cause specific or overall). Presence or absence of adjustment for smoking and socioeconomic status was not a source of heterogeneity in the primary studies. 6598 myocardial infarctions, 17,359 coronary events, and 1854 ischaemic strokes occurred. On the basis of the Canadian prevalence of shift work of 32.8%, the population attributable risks related to shift work were 7.0% for myocardial infarction, 7.3% for all coronary events, and 1.6% for ischaemic stroke.

conclusionsShift work is associated with vascular events, which may have implications for public policy and occupational medicine.

Indexed as

Personnel Staffing and SchedulingWork Schedule ToleranceBrain IschemiaCoronary DiseaseHumansMyocardial InfarctionOdds RatioRisk AssessmentRisk FactorsStroke

Identifiers

PMID22835925
PMCPMC3406223
OpenAlexW2119434070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.