ReviewCurrent opinion in structural biology2012
Go hybrid: EM, crystallography, and beyond.
Review in Current opinion in structural biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Epitope mapping of diagnostic antibodies targeting SARS-CoV-2 nucleocapsid protein using hydrogen-deuterium exchange mass spectrometry.Biophysical journal · 2025Article
- Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae.Journal of visualized experiments : JoVE · 2018Article
- Article
- γ-TEMPy: Simultaneous Fitting of Components in 3D-EM Maps of Their Assembly Using a Genetic Algorithm.Structure (London, England : 1993) · 2015Article
- Article
- Topological models of heteromeric protein assemblies from mass spectrometry: application to the yeast eIF3:eIF5 complex.Chemistry & biology · 2015Article
- Signal transduction: From the atomic age to the post-genomic era.Cold Spring Harbor perspectives in biology · 2014Review
- Deep mutational scanning: a new style of protein science.Nature methods · 2014Article
- Optimod--an automated approach for constructing and optimizing initial models for single-particle electron microscopy.Journal of structural biology · 2013Article
- High-resolution network biology: connecting sequence with function.Nature reviews. Genetics · 2013Review
- Conformational States of macromolecular assemblies explored by integrative structure calculation.Structure (London, England : 1993) · 2013Article
- Modeling stochastic kinetics of molecular machines at multiple levels: from molecules to modules.Biophysical journal · 2013Review
- Biochemistry. Integrative structural biology.Science (New York, N.Y.) · 2013Article
- Structure, assembly and dynamics of macromolecular complexes by single particle cryo-electron microscopy.Journal of nanobiotechnology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
A mechanistic understanding of the molecular transactions that govern cellular function requires knowledge of the dynamic organization of the macromolecular machines involved in these processes. Structural biologists employ a variety of biophysical methods to study large macromolecular complexes, but no single technique is likely to provide a complete description of the structure-function relationship of all the constituent components. Since structural studies generally only provide snapshots of these dynamic machines as they accomplish their molecular functions, combining data from many methodologies is crucial to our understanding of molecular function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.