Evidence map›Paper›PMID 22835544›Full record

ReviewDental clinics of North America2012

Therapeutic potential of mesenchymal stem cells for oral and systemic diseases.

Reuben H Kim, Shebli Mehrazarin, Mo K Kang

Open access · greenAbstract readReview
In one paragraph

Review in Dental clinics of North America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

  1. Mesenchymal Stem Cell Therapy for Oral Lichen Planus: A Paradigm Shift from Palliation to Regeneration.International journal of hematology-oncology and stem cell research · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Odontogenic epithelial stem cells: hidden sources.Laboratory investigation; a journal of technical methods and pathology · 2015
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Reuben H KimDivision of Restorative Dentistry, University of California Los Angeles School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
Shebli Mehrazarin
Mo K Kang
University of California, Los Angeles · US

Funding

Effects of Antiretroviral Therapy on Telomerase Function in Human Oral EpitheliumR01DE018295 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KANG, MO K. · 2007 to 2011
$1.7M
Phenotypic and genetic effects of antiretroviral therapy on human oral epitheliumK02DE018959 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KANG, MO K. · 2008 to 2012
$486k
NIDCR NIH HHS DE18295NIDCR NIH HHS DE18959NIDCR NIH HHS K02 DE018959NIDCR NIH HHS R01 DE018295
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are adult stem cells whose self-renewal, multipotency, and immunosuppressive functions have been investigated for therapeutic applications. MSCs have used for various systemic organ regenerative therapies, allowing rescue of tissue function in damaged or failing organs. This article reviews the regenerative and immunomodulatory functions of MSCs and their applications in dental, orofacial, and systemic tissue regeneration and treatment of inflammatory disorders. It also addresses challenges to MSC-mediated therapeutics arising from tissue and MSC aging and host immune response against allogenic MSC transplantation, and discusses alternative sources of MSCs aimed at overcoming these limitations.

Indexed as

Autoimmune DiseasesCell DifferentiationDental Pulp CappingDentitionHumansMesenchymal Stem CellsMouth DiseasesRegenerative MedicineSkin DiseasesTissue Engineering

Identifiers

PMID22835544
PMCPMC3426923
OpenAlexW1990497696

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.