Evidence map›Paper›PMID 22835460›Full record

ReviewSeminars in nephrology2012

Retinoid and TGF-β families: crosstalk in development, neoplasia, immunity, and tissue repair.

Qihe Xu, Jeffrey B Kopp

Abstract readReview
In one paragraph

Review in Seminars in nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. The Influences of RARγ on the Behavior of Normal and Cancer Stem Cells.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. All-International journal of molecular sciences · 2022
    Article
  9. Article
  10. Isotretinoin and Thalidomide Down-RegulateMolecules (Basel, Switzerland) · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Disparate roles of retinoid acid signaling molecules in kidney disease.American journal of physiology. Renal physiology · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Qihe XuDepartment of Renal Medicine, King's College London, London, UK.
Jeffrey B Kopp

Funding

Focal Segmental Glomerulosclerosis: Genetics & MechanismsZIADK043308 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KOPP, JEFFREY BURNETT · 2009 to 2024
$15.7M
Focal segmental glomerulosclerosis: TreatmentZIADK043412 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KOPP, JEFFREY BURNETT · 2009 to 2024
$7.4M
Intramural NIH HHS ZIA DK043412
6 · The paper itself

Abstract

Transforming growth factor-β (TGF-β) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, physiology, and disease. The interactions between these classes of molecules are, not surprisingly, highly complex and are dependent on the tissue, cellular, and molecular settings.

Indexed as

Embryonic DevelopmentFetal DevelopmentHumansNeoplasmsReceptors, Retinoic AcidRetinoidsRetinoid X ReceptorsSignal TransductionTransforming Growth Factor betaTretinoinVitamin AWound HealingReceptors, Retinoic AcidRetinoidsRetinoid X ReceptorsTransforming Growth Factor betaTretinoinVitamin A

Identifiers

PMID22835460
PMCPMC3407374

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.