Trial reportBMC nephrology2012
Cancer risk among elderly persons with end-stage renal disease: a population-based case-control study.
Trial report in BMC nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies.BMC cancer · 2016Pooled it
- Effect of gout and diabetic kidney disease on renal cancer development in Korea.Clinical kidney journal · 2024Article
- Real-world survival after colorectal surgery for malignancy in Korean patients with chronic kidney disease: an analysis of Korean healthcare big data, 2002-2019.Annals of surgical treatment and research · 2023Article
- Effects of p-cresol, a uremic toxin, on cancer cells.Translational cancer research · 2023Article
- Appraisal of lung cancer survival in patients with end-stage renal disease.Archives of medical science : AMS · 2023Article
- A glance at the emerging diagnostic biomarkers in the most prevalent genitourinary cancers.Saudi journal of biological sciences · 2022Review
- Risk of malignancy in patients with chronic kidney disease.PloS one · 2022Article
- Cancer incidence according to the National Health Information Database in Korean patients with end-stage renal disease receiving hemodialysis.The Korean journal of internal medicine · 2020Article
- The association of the decline in glomerular filtration rate with aggressive endometrial cancers.International urology and nephrology · 2020Article
- Higher risk of malignant neoplasms in young adults with end-stage renal disease receiving haemodialysis: A nationwide population-based study.Nephrology (Carlton, Vic.) · 2019Article
- Peritoneal Dialysis and Malignancy: An Experience With a Patient Complicated by Gastric Carcinoma.Clinical medicine insights. Case reports · 2019Article
- Colonoscopy as Part of Pre-Transplant Work-Up in Successful Kidney Transplant Candidates: Single-Center Experience and Review of Literature.Annals of transplantation · 2018Article
- Epidemiology and Risk Factors for Kidney Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Review
- Effect of mechanistic target of rapamycin inhibitors on postrenal transplantation malignancy: A nationwide cohort study.Cancer medicine · 2018Article
- Is there different risk of cancer among end-stage renal disease patients undergoing hemodialysis and peritoneal dialysis?Cancer medicine · 2018Article
- Dialysis physicians' referral behaviors for hemodialysis patients suspected of having cancer: A vignette-based questionnaire study.PloS one · 2018Article
- Association between chronic kidney disease and cancer mortality: A report from the ALLHAT.Clinical nephrology · 2017Article
- Smoking, depression, and hospital costs of respiratory cancers: Examining race and sex variation.Family medicine and community health · 2017Article
- Variation in Cancer Incidence among Patients with ESRD during Kidney Function and Nonfunction Intervals.Journal of the American Society of Nephrology : JASN · 2016Article
- Cancer incidence among US Medicare ESRD patients receiving hemodialysis, 1996-2009.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with end-stage renal disease (ESRD) have elevated cancer risk. Cancer risk increases with age, but associations of ESRD with specific malignancies are incompletely studied for older individuals.
methodsWe conducted a population-based case-control study (1,029,695 cancer and 99,610 controls) among the U.S. elderly using SEER-Medicare linked data. We defined ESRD as presence of dialysis claims in the 3 months prior to selection.
resultsAlthough ESRD was not associated with excess cancer risk overall (odds ratio 1.02; 95%CI 0.91-1.14), risk was specifically increased for cancers of the stomach (1.45; 1.16-1.81), small intestine (1.92; 1.27-2.92), colon (1.17; 1.00-1.36), liver (1.53; 1.16-2.01), biliary tract (1.78; 1.20-2.65), lung (1.17; 1.02-1.34), cervix (2.12; 1.39-3.23), kidney (2.42; 2.01-2.92), and for multiple myeloma (1.77; 1.40-2.24) and chronic myeloid leukemia (1.74; 1.08-2.80). The association between liver cancer and ESRD was attenuated upon adjustment for hepatitis B and C infection or diabetes mellitus. Multiple myeloma risk was highest with short ESRD duration (p < 0.0001), possibly reflecting reverse causality, while kidney cancer risk showed a borderline rise over time (p = 0.08).
conclusionsAmong elderly individuals with ESRD, the excess risks for some cancers may reflect immune dysfunction or a high prevalence of other risk factors, such as viral infections or diabetes mellitus. Our results underscore the need for studying biological pathways of carcinogenesis in ESRD.
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