Evidence map›Paper›PMID 22834730›Full record

ArticleTissue engineering. Part A2013

Effect of an adipose-derived stem cell and nerve growth factor-incorporated hydrogel on recovery of erectile function in a rat model of cavernous nerve injury.

In Gul Kim, Shuyu Piao, Ji Young Lee, Sung Hoo Hong, Tae-Kon Hwang, Sae Woong Kim, Choung Soo Kim, Jeong Chan Ra, Insup Noh, Ji Youl Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  10. Sciatic Nerve Plastic Surgery using Autologous Adipose Tissue.Sovremennye tekhnologii v meditsine · 2023
    Article
  11. Article
  12. Review
  13. Stem-cell therapy for erectile dysfunction: a review of clinical outcomes.International journal of impotence research · 2021
    Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

In Gul KimDepartment of Urology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Shuyu Piao
Ji Young Lee
Sung Hoo Hong
Tae-Kon Hwang
Sae Woong Kim
Choung Soo Kim
Jeong Chan Ra
Insup Noh
Ji Youl Lee
The Catholic University of Korea Seoul St. Mary's Hospital · KRSeoul National University of Science and Technology · KRUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postprostatectomy erectile dysfunction (ED) is the major problem for patients with clinically localized prostate cancer. Recently, gene and stem cell-based therapy of the corpus cavernosum has been attempted for postprostatectomy ED, but those therapies are limited by rapid blood flow and disruption of the normal architecture of the corpus cavernosum. In this study, we attempted to regenerate the damaged cavernous nerve (CN), which is the main cause of ED. We investigated the effectiveness of human adipose-derived stem cell (hADSC) and nerve growth factor-incorporated hyaluronic acid-based hydrogel (NGF-hydrogel) application on the CN in a rat model of bilateral cavernous nerve crush injury. Four weeks after the operation, erectile function was assessed by detecting the intracavernous pressure (ICP)/arterial pressure level by CN electrostimulation. The ICP was significantly increased by application of hADSC with NGF-hydrogel compared to the other experimental groups. CN and penile tissue were collected for histological examination. PKH-26 labeled hADSC colocalized with beta III tubulin were shown in CN tissue sections. hADSC/NGF-hydrogel treatment prevented smooth muscle atrophy in the corpus cavernosum. In addition, the hADSC/NGF-hydrogel group showed increased endothelial nitric oxide synthase protein expression. This study suggests that application of hADSCs with NGF-hydrogel on the CN might be a promising treatment for postprostatectomy ED.

Indexed as

AdipocytesAnimalsCells, CulturedCombined Modality TherapyDrug CarriersErectile DysfunctionHumansHydrogelsMaleNerve Growth FactorPeripheral Nerve InjuriesProstatectomyRatsRats, Sprague-DawleyRecovery of FunctionStem Cell TransplantationDrug CarriersHydrogelsNerve Growth Factor

Identifiers

PMID22834730
PMCPMC3530933
OpenAlexW2060634779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.