ArticleJournal of thoracic disease2012
Establishment of an orthotopic lung cancer model in nude mice and its evaluation by spiral CT.
Article in Journal of thoracic disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Establishment and characterization of an orthotopic implanted lung cancer model to mimic human tumor structure, microenvironment, and metastatic spread.Translational lung cancer research · 2025Article
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- A mouse model of lung cancer induced via intranasal injection for anticancer drug screening and evaluation of pathology.FEBS open bio · 2023Article
- Validity of the peak velocity to detect physical training improvements in athymic mice.Frontiers in physiology · 2022Article
- Automated monitoring of respiratory rate as a novel humane endpoint: A refinement in mouse metastatic lung cancer models.PloS one · 2021Article
- Synthesis, radiolabelling, and biological assessment of folic acid-conjugated G-3IET nanobiotechnology · 2020Article
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- Pre-clinical imaging for establishment and comparison of orthotopic non-small cell lung carcinoma: in search for models reflecting clinical scenarios.The British journal of radiology · 2019Article
- Does the mouse tail vein injection method provide a good model of lung cancer?F1000Research · 2019Article
- Establishment and evaluation of the VX2 orthotopic lung cancer rabbit model: a ultra-minimal invasive percutaneous puncture inoculation method.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Technetium-99m chelator-free radiolabeling of specific glutamine tumor imaging nanoprobe: in vitro and in vivo evaluations.International journal of nanomedicine · 2018Article
- ImmunoPET Imaging of CD146 in Murine Models of Intrapulmonary Metastasis of Non-Small Cell Lung Cancer.Molecular pharmaceutics · 2017Article
- Immunotoxin Therapy for Lung Cancer.Chinese medical journal · 2017Article
- An orthotopic mouse model of small cell lung cancer reflects the clinical course in patients.Clinical & experimental metastasis · 2016Article
- Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis.Breast cancer research : BCR · 2015Article
- Article
- Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics.Current protocols in pharmacology · 2013Article
- The efficacy of the inhalation of an aerosolized Group A streptococcal preparation in the treatment of lung cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2012Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo establish a simple and highly efficient orthotopic animal model of lung cancer cell line A549 and evaluate the growth pattern of intrathoracic tumors by spiral CT.
methodsA549 cells (5×10(6) mL(-1)) were suspended and inoculated into the right lung of BALB/c nude mice via intrathoracic injection. Nude mice were scanned three times each week by spiral CT after inoculation of lung cancer cell line A549. The survival time and body weight of nude mice as well as tumor invasion and metastasis were examined. Tissue was collected for subsequent histological assay after autopsia of mice.
resultsThe tumor-forming rate of the orthotopic lung cancer model was 90%. The median survival time was 30.7 (range, 20-41) days. The incidence of tumor metastasis was 100%. The mean tumor diameter and the average CT value gradually increased in a time-dependent manner.
conclusionsThe method of establishing the orthotopic lung cancer model through transplanting A549 cells into the lung of nude mice is simple and highly successful. Spiral CT can be used to evaluate intrathoracic tumor growth in nude mice vividly and dynamically.
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