ArticleClinical kidney journal2012
Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A(2) receptor antibody-positive membranous nephropathy.
Article in Clinical kidney journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- The Prevalence, Characteristics, and Putative Mechanisms of Dual Antigen-Positive Membranous Nephropathy: The Underestimated Condition.International journal of molecular sciences · 2024Review
- Thrombotic thrombocytopenic purpura developed during the conservative treatment of anti-phospholipase ABMC nephrology · 2020Article
- Membranous Glomerulonephritis With Crescents.Kidney international reports · 2019Article
- Anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with detection of myeloperoxidase and phospholipase ABMC nephrology · 2018Article
- Clinical Features and Outcomes in Patients With Membranous Nephropathy and Crescent Formation.Medicine · 2015Observational
- Crescentic glomerulonephritis and membranous nephropathy: a rare coexistence.International urology and nephrology · 2015Article
- Membranous Nephropathy With MPO-ANCA-Associated Crescentic GN.Nephro-urology monthly · 2014Article
- Membranous glomerulonephritis with crescents.International urology and nephrology · 2014Article
- Membranous nephropathy superimposed on Churg-Strauss syndrome.Indian journal of nephrology · 2014Article
- Combined membranous nephropathy and crescentic glomerulonephritis with concurrent anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody.CEN case reports · 2013Article
- Pathophysiological lessons from rare associations of autoimmune diseases.Clinical kidney journal · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Antibodies to myeloperoxidase (MPO) and proteinase 3 (PR3) have been demonstrated to mediate anti-neutrophil cytoplasmic antibody (ANCA)-associated disease. For membranous nephropathy, antibodies to the podocyte-expressed phospholipase A(2) receptor (anti-PLA(2)R) are highly associated with disease activity and have been reported in at least 70% of patients with idiopathic membranous nephropathy (IMN). We present a case of a 56-year-old male with a 1 year history of hypertension, leg edema, and proteinuria, who presented with advanced renal failure and was found to have both ANCA-associated glomerulonephritis (GN) and IMN on kidney biopsy. Consistent with the idea that this is due to the chance occurrence of two independent diseases, we found both anti-MPO and anti-PLA(2)R antibodies in the patient's sera. Treatment with methylprednisolone, plasmapheresis, and cyclophosphamide resulted in improvement in kidney function and proteinuria, together with the simultaneous decrease in both autoantibodies. This is the first demonstration of two pathogenic antibodies giving rise to ANCA-associated GN and IMN in the same patient. It confirms the importance of classifying disease based upon the underlying mechanism, in addition to renal histopathology, to both optimize therapy and predict prognosis.
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Registered trials
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