ArticleThe Journal of biological chemistry2012
Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The Effects of Cannabis on Female Reproductive Health Across the Life Course.Cannabis and cannabinoid research · 2021Pooled it
- Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta.Clinical pharmacology and therapeutics · 2026Article
- Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy.International journal of molecular sciences · 2023Review
- Effects of Prenatal Cannabinoids Exposure upon Placenta and Development of Respiratory Neural Circuits.Advances in experimental medicine and biology · 2023Review
- Preeclampsia Correlates with an Increase in Cannabinoid Receptor 1 Levels Leading to Macromolecular Alterations in Chorionic Villi of Term Placenta.International journal of molecular sciences · 2022Article
- Cannabinoid and planar cell polarity signaling converges to direct placentation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System.International journal of molecular sciences · 2021Review
- Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.Molecular biology and evolution · 2020Article
- Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis.Pharmacological research · 2019Article
- Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The grass isn't always greener: The effects of cannabis on embryological development.BMC pharmacology & toxicology · 2016Review
- Marijuana, the Endocannabinoid System and the Female Reproductive System.The Yale journal of biology and medicine · 2016Review
- Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth.The Journal of biological chemistry · 2016Article
- SNaPP: Simplified Nanoproteomics Platform for Reproducible Global Proteomic Analysis of Nanogram Protein Quantities.Endocrinology · 2016Article
- Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation.PloS one · 2016Article
- Inhibition of FAAH confers increased stem cell migration via PPARα.Journal of lipid research · 2015Article
- Decreased circulating anandamide levels in preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Endocannabinoid signaling at the periphery: 50 years after THC.Trends in pharmacological sciences · 2015Review
- Preferential epithelial expression of type-1 cannabinoid receptor (CB1R) in the developing canine embryo.SpringerPlus · 2015Article
- Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study.BMC pregnancy and childbirth · 2014Observational
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Endocannabinoid signaling plays key roles in multiple female reproductive events. Previous studies have shown an interesting phenomenon, that mice with either silenced or elevated endocannabinoid signaling via Cnr1 encoding CB(1) show similar defects in several pregnancy events, including preimplantation embryo development. To unravel the downstream signaling of this phenomenon, microarray studies were performed using RNAs collected from WT, Cnr1(-/-), and Faah(-/-) mouse blastocysts on day 4 of pregnancy. The results indicate that about 100 genes show unidirectional changes under either silenced or elevated anandamide signaling via CB(1). Functional enrichment analysis of the microarray data predicted that multiple biological functions and pathways are affected under aberrant endocannabinoid signaling. Among them, genes enriched in cell migration are suppressed in Cnr1(-/-) or Faah(-/-) blastocysts. Cell migration assays validated the prediction of functional enrichment analysis that cell mobility and spreading of either Cnr1(-/-) or Faah(-/-) trophoblast stem cells are compromised. Either silenced or elevated endocannabinoid signaling via CB(1) causes similar changes in downstream targets in preimplantation embryos and trophoblast stem cells. This study provides evidence that a tightly regulated endocannabinoid signaling is critical to normal preimplantation embryo development and migration of trophoblast stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.