ArticleCephalalgia : an international journal of headache2012
Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells.
Article in Cephalalgia : an international journal of headache, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Giving Researchers a Headache - Sex and Gender Differences in Migraine.Frontiers in neurology · 2020Pooled it
- Review
- Spreading depolarization activates the cGAS-STING pathway and drives cranial nociception: therapeutic potential of STING modulation.The journal of headache and pain · 2026Article
- Meningeal brain borders and migraine headache genesis.Trends in neurosciences · 2024Review
- Topiramate Inhibits Capsaicin-Induced Mast Cell Degranulation and CGRP Release in Rat Dura Mater.Brain sciences · 2024Article
- Sex Differences in Mast Cell-Associated Disorders: A Life Span Perspective.Cold Spring Harbor perspectives in biology · 2022Review
- Histomorphometry of mast cells in the convexity of human intracranial dura mater.Journal of anatomy · 2022Article
- Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats.Biology of sex differences · 2021Article
- The trigeminal system: The meningovascular complex- A review.Journal of anatomy · 2021Review
- Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Enhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury.Cephalalgia : an international journal of headache · 2020Article
- Review
- Gender aspects of CGRP in migraine.Cephalalgia : an international journal of headache · 2019Review
- Investigation of Gene Expression and DNA Methylation From Seven Different Brain Regions of a Crab-Eating Monkey as Determined by RNA-Seq and Whole-Genome Bisulfite Sequencing.Frontiers in genetics · 2019Article
- Neurogenic inflammation and its role in migraine.Seminars in immunopathology · 2018Review
- Mast cell-neural interactions contribute to pain and itch.Immunological reviews · 2018Review
- Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease.American journal of physiology. Heart and circulatory physiology · 2017Review
- Estrogen-Dependent Changes in Dura Mater Microvasculature Add New Insights to the Pathogenesis of Headache.Frontiers in neurology · 2017Review
- Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura.Cephalalgia : an international journal of headache · 2017Article
- Cholinergic Nociceptive Mechanisms in Rat Meninges and Trigeminal Ganglia: Potential Implications for Migraine Pain.Frontiers in neurology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe frequency of migraine headaches is higher in women than in men and in susceptible women attacks are related to changes in ovarian hormone levels. Intracranial mast cells (MCs) are likely to have a role in migraine headache genesis, and changes in the dural MC population might influence headache susceptibility. The present study thus tested the hypothesis that sex and ovarian hormones influence the density and phenotypic makeup of dural MCs.
methodsHistochemistry combined with quantitative analyses was used to investigate sex differences, estrous cycle and ovarian hormones on dural MC density, phenotype and degranulation level in male and female rats.
resultsOur data show that in female rats, dural MC density fluctuates during the estrous cycle and is overall higher than in males. In ovariectomized rats, estradiol, but not progesterone, promoted an increase in dural MC density. This effect was abolished by a splenectomy, suggesting estrogen-related recruitment of MCs from the spleen. Finally, our data suggest that the phenotypic make up of dural MCs, which represents the level of cellular maturity, is also governed by changes in estrogen levels.
conclusionsGiven the potential role of dural MCs in triggering headache, our data suggest that estrogen-related modulation of dural MC density and phenotypic makeup could have a role in mediating the higher frequency and severity of headaches such as migraine, in women.
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Registered trials
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