ArticleMolecular biology of the cell2012
Placenta to cartilage: direct conversion of human placenta to chondrocytes with transformation by defined factors.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Screening of Biomarkers Associated with Osteoarthritis Aging Genes and Immune Correlation Studies.International journal of general medicine · 2024Article
- GANT-61 induces cell cycle resting and autophagy by down-regulating RNAP III signal pathway and tRNA-Gly-CCC synthesis to combate chondrosarcoma.Cell death & disease · 2023Article
- Direct Reprogramming of Mouse Subchondral Bone Osteoblasts into Chondrocyte-like Cells.Biomedicines · 2022Article
- The Chondrogenic Potential of First-Trimester and Term Placental Mesenchymal Stem/Stromal Cells.Cartilage · 2021Article
- Overcoming Current Dilemma in Cartilage Regeneration: Will Direct Conversion Provide a Breakthrough?Tissue engineering and regenerative medicine · 2020Review
- Elucidation of Biochemical Pathways Underlying VOCs Production in A549 Cells.Frontiers in molecular biosciences · 2020Article
- Direct conversion of pig fibroblasts to chondrocyte-like cells by c-Myc.Cell death discovery · 2019Article
- Comprehensive transcriptome mining of the direct conversion of mesodermal cells.Scientific reports · 2017Article
- Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors.Stem cell reports · 2017Article
- Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons.Stem cells international · 2016Article
- Internalization of isolated functional mitochondria: involvement of macropinocytosis.Journal of cellular and molecular medicine · 2014Article
- Phenotypic plasticity in normal breast derived epithelial cells.BMC cell biology · 2014Article
- Sox9 reprogrammed dermal fibroblasts undergo hypertrophic differentiation in vitro and trigger endochondral ossification in vivo.Cellular reprogramming · 2014Article
- Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment.Journal of tissue engineering · 2014Review
- β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells.PloS one · 2013Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. We hypothesized that combinatorial expression of chondrocyte-specific transcription factors could directly convert human placental cells into chondrocytes. Starting from a pool of candidate genes, we identified a combination of only five genes (5F pool)-BCL6, T (also called BRACHYURY), c-MYC, MITF, and BAF60C (also called SMARCD3)-that rapidly and efficiently convert postnatal human chorion and decidual cells into chondrocytes. The cells generated expressed multiple cartilage-specific genes, such as Collagen type II α1, LINK PROTEIN-1, and AGGRECAN, and exhibited characteristics of cartilage both in vivo and in vitro. Expression of the endogenous genes for T and MITF was initiated, implying that the cell conversion is due to not only the forced expression of the transgenes, but also to cellular reprogramming by the transgenes. This direct conversion system from noncartilage tissue to cartilaginous tissue is a substantial advance toward understanding cartilage development, cell-based therapy, and oncogenesis of chondrocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.