Evidence map›Paper›PMID 22833496›Full record

ArticleBriefings in bioinformatics2012

Mining the pharmacogenomics literature--a survey of the state of the art.

Udo Hahn, K Bretonnel Cohen, Yael Garten, Nigam H Shah

Abstract read
In one paragraph

Article in Briefings in bioinformatics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. An Overview of Biomolecular Event Extraction from Scientific Documents.Computational and mathematical methods in medicine · 2015
    Review
  10. Article
  11. Big data in medicine is driving big changes.Yearbook of medical informatics · 2014
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Udo HahnJena University Language and Information Engineering (JULIE) Lab, Friedrich-Schiller-Universität Jena, Jena, Germany. udo.hahn@uni-jena.de
K Bretonnel Cohen
Yael Garten
Nigam H Shah

Funding

STANFORD COMPOSITE(RMI)U54HG004028 · NHGRI · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2005 to 2014
$36.2M
PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2M
THE STANFORD PHARMACOGENETICS KNOWLEDGE BASEU01GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2000 to 2009
$24.0M
Technology Development for a MolBio Knowledge-BaseR01LM008111 · NLM · UNIVERSITY OF COLORADO DENVER · PI HUNTER, LAWRENCE E · 2004 to 2021
$9.7M
Bio Text NLPR01LM009254 · NLM · UNIVERSITY OF COLORADO DENVER · PI HUNTER, LAWRENCE E · 2006 to 2018
$5.9M
Ontologies and Biomedical Language ProcessingR01GM083649 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI HUNTER, LAWRENCE E · 2007 to 2010
$2.5M
NHGRI NIH HHS U54 HG004028NHGRI NIH HHS U54-HG004028NIGMS NIH HHS 5R01 GM083649-04NIGMS NIH HHS GM61374NIGMS NIH HHS R01 GM083649NIGMS NIH HHS R24 GM061374NIGMS NIH HHS U01 GM061374NLM NIH HHS 5R01 LM008111-07NLM NIH HHS 5R01 LM009254-06NLM NIH HHS HHSN276201000025CNLM NIH HHS R01 LM008111NLM NIH HHS R01 LM009254
6 · The paper itself

Abstract

This article surveys efforts on text mining of the pharmacogenomics literature, mainly from the period 2008 to 2011. Pharmacogenomics (or pharmacogenetics) is the field that studies how human genetic variation impacts drug response. Therefore, publications span the intersection of research in genotypes, phenotypes and pharmacology, a topic that has increasingly become a focus of active research in recent years. This survey covers efforts dealing with the automatic recognition of relevant named entities (e.g. genes, gene variants and proteins, diseases and other pathological phenomena, drugs and other chemicals relevant for medical treatment), as well as various forms of relations between them. A wide range of text genres is considered, such as scientific publications (abstracts, as well as full texts), patent texts and clinical narratives. We also discuss infrastructure and resources needed for advanced text analytics, e.g. document corpora annotated with corresponding semantic metadata (gold standards and training data), biomedical terminologies and ontologies providing domain-specific background knowledge at different levels of formality and specificity, software architectures for building complex and scalable text analytics pipelines and Web services grounded to them, as well as comprehensive ways to disseminate and interact with the typically huge amounts of semiformal knowledge structures extracted by text mining tools. Finally, we consider some of the novel applications that have already been developed in the field of pharmacogenomic text mining and point out perspectives for future research.

Indexed as

PharmacogeneticsData CollectionData MiningInformation Storage and RetrievalNatural Language ProcessingPublicationsSemantics

Identifiers

PMID22833496
PMCPMC3404399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.