ArticleJournal of cell communication and signaling2012
CCN1 and CCN2: blood brothers in angiogenic action.
Article in Journal of cell communication and signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed.
- Alcohol exposure promotes cell communication network 1 cleavage in esophageal adenocarcinoma cells exclusively.Journal of cell communication and signaling · 2026Article
- Plasminogen activator inhibitor 1 promotes aortic aging-like pathophysiology in humans and mice.The Journal of clinical investigation · 2025Article
- Microvascular Endothelial Cells License APS Vasculopathy Through YAP1- and CCN2-Mediated Signaling.Circulation · 2025Article
- Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors.EMBO molecular medicine · 2023Article
- Shedding light on the role of keratinocyte-derived extracellular vesicles on skin-homing cells.Stem cell research & therapy · 2020Review
- The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling.The Journal of biological chemistry · 2018Article
- Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review).Molecular medicine reports · 2018Review
- CCN3 promotes epithelial-mesenchymal transition in prostate cancer via FAK/Akt/HIF-1α-induced twist expression.Oncotarget · 2017Article
- Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells.Translational research : the journal of laboratory and clinical medicine · 2016Article
- Human pancreatic cancer progression: an anarchy among CCN-siblings.Journal of cell communication and signaling · 2016Article
- Keratinocyte Microvesicles Regulate the Expression of Multiple Genes in Dermal Fibroblasts.The Journal of investigative dermatology · 2015Article
- Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities.Human genomics · 2015Review
- Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia.The Journal of biological chemistry · 2015Article
- The Role of Genetically Modified Mesenchymal Stem Cells in Urinary Bladder Regeneration.PloS one · 2015Article
- Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Pancreatic tumor cell secreted CCN1/Cyr61 promotes endothelial cell migration and aberrant neovascularization.Scientific reports · 2014Article
- PTH promotes allograft integration in a calvarial bone defect.Molecular pharmaceutics · 2013Article
- Molecular control of vascular development by the matricellular proteinsTrends in developmental biology · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
CCN2/connective tissue growth factor (CTGF) is a matricellular protein essential for skeletal development during embryogenesis. In adulthood, aberrant CCN2 expression is associated with many malignancies and fibrosis of virtually every organ. Despite its prominent expression in endothelial cells in the vasculature, the role of CCN2 in vessel development was unknown. In a recent study, Hall-Glenn et al. (PLoS ONE 7:e30562) have revealed the role of CCN2 in developmental angiogenesis through a detailed analysis of how CCN2 mediates the interaction between vascular endothelial cells and pericytes. In addition, CCN2 also regulates endothelial basement membrane formation during vessel formation. Here I compare the angiogenic activities of CCN2 during embryogenesis to those of its homologous family member CCN1 (CYR61), which is essential for cardiovascular development. Understanding the angiogenic actions of CCN1 and CCN2 may have implication in the development of therapeutic strategies targeting these proteins for the treatment of diseases such as cancer and fibrosis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.