ArticleTranslational psychiatry2011
BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals.
Article in Translational psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Review
- Article
- Genetic analysis of potential biomarkers and therapeutic targets in neuroinflammation from sporadic Creutzfeldt-Jakob disease.Scientific reports · 2023Article
- Investigating Predictors of Cognitive Decline Using Machine Learning.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Article
- Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging.Neurobiology of disease · 2019Review
- The Potential Role of Genetic Markers in Talent Identification and Athlete Assessment in Elite Sport.Sports (Basel, Switzerland) · 2018Review
- BDNF genotype is associated with hippocampal volume in mild traumatic brain injury.Genes, brain, and behavior · 2018Article
- Exercise-Mediated Neurogenesis in the Hippocampus via BDNF.Frontiers in neuroscience · 2018Review
- Decreased hippocampal brain-derived neurotrophic factor and impaired cognitive function by hypoglossal nerve transection in rats.Journal of cellular and molecular medicine · 2017Article
- The Impact of the Brain-Derived Neurotrophic Factor Gene on Trauma and Spatial Processing.Journal of clinical medicine · 2017Article
- Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.Psychoneuroendocrinology · 2017Article
- Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development.Vitamins and hormones · 2017Review
- Brain-derived neurotrophic factor differentially modulates excitability of two classes of hippocampal output neurons.Journal of neurophysiology · 2016Article
- DNA methylation and cognitive aging.Oncotarget · 2015Review
- Genetics and functional imaging: effects of APOE, BDNF, COMT, and KIBRA in aging.Neuropsychology review · 2015Review
- Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice.Behavioural brain research · 2014Article
- PTSD recovery, spatial processing, and the val66met polymorphism.Frontiers in human neuroscience · 2014Article
- Article
- Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling.Frontiers in cellular neuroscience · 2014Review
- BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.Nature reviews. Neuroscience · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Numerous studies have indicated a link between the presence of polymorphism in brain-derived neurotrophic factor (BDNF) and cognitive and affective disorders. However, only a few have studied these effects longitudinally along with structural changes in the brain. This study was carried out to investigate whether valine-to-methionine substitution at position 66 (val66met) of pro-BDNF could be linked to alterations in the rate of decline in skilled task performance and structural changes in hippocampal volume. Participants consisted of 144 healthy Caucasian pilots (aged 40-69 years) who completed a minimum of 3 consecutive annual visits. Standardized flight simulator score (SFSS) was measured as a reliable and quantifiable indicator for skilled task performance. In addition, a subset of these individuals was assessed for hippocampal volume alterations using magnetic resonance imaging. We found that val66met substitution in BDNF correlated longitudinally with the rate of decline in SFSS. Structurally, age-dependent hippocampal volume changes were also significantly altered by this substitution. Our study suggests that val66met polymorphism in BDNF can be linked to the rate of decline in skilled task performance. Furthermore, this polymorphism could be used as a predictor of the effects of age on the structure of the hippocampus in healthy individuals. Such results have implications for understanding possible disabilities in older adults performing skilled tasks who are at a higher risk for cognitive and affective disorders.Translational Psychiatry (2011) 1, e51; doi:10.1038/tp.2011.47; published online 25 October 2011.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.