SynthesisTranslational psychiatry2011
Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.
Synthesis in Translational psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- GWA meta-analysis of personality in Korean cohorts.Journal of human genetics · 2015Pooled it
- Review
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- Substance Use and Attendance Motives of Electronic Dance Music (EDM) Event Attendees: A Survey Study.International journal of environmental research and public health · 2023Article
- Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Association between Polymorphism rs1799732 ofInternational journal of environmental research and public health · 2022Article
- Serotonin ReceptorInternational journal of environmental research and public health · 2022Article
- Inferring miRNA sponge modules across major neuropsychiatric disorders.Frontiers in molecular neuroscience · 2022Article
- Infant inhibited temperament in primates predicts adult behavior, is heritable, and is associated with anxiety-relevant genetic variation.Molecular psychiatry · 2021Article
- Detecting Genetic Ancestry and Adaptation in the Taiwanese Han People.Molecular biology and evolution · 2021Article
- Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.Molecular psychiatry · 2021Article
- Selection signatures of Fuzhong Buffalo based on whole-genome sequences.BMC genomics · 2020Article
- Dopamine Receptor DRD2 Gene rs1076560, Personality Traits and Anxiety in the Polysubstance Use Disorder.Brain sciences · 2020Article
- Personality Traits or Genetic Determinants-Which Strongly Influences E-Cigarette Users?International journal of environmental research and public health · 2020Article
- Associations between the dopamine D4 receptor gene polymorphisms and personality traits in elite athletes.Biology of sport · 2019Article
- Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients.International journal of environmental research and public health · 2018Article
- Genetics of biologically based psychological differences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
Corrections and comments
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Authors and funding
41 authors.
Funding
Abstract
The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (N=7860), and combined the results in a meta-analysis. We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 (P=2 × 10(-8)). This single-nucleotide polymorphism maps within the catenin cadherin-associated protein, alpha 2 (CTNNA2) gene, which encodes for a brain-expressed α-catenin critical for synaptic contact. The effect of rs7600563 was in the same direction in all six samples, but did not replicate in additional samples (N=5105). The results provide insight into the genetics of excitement-seeking and risk-taking, and are relevant to hyperactivity, substance use, antisocial and bipolar disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.