ArticleDevelopment (Cambridge, England)2012
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- Review
- Article
- Ribosome heterogeneity and specialization in development.Wiley interdisciplinary reviews. RNA · 2021Review
- eIF4E and Interactors from Unicellular Eukaryotes.International journal of molecular sciences · 2020Review
- Article
- Article
- Maintenance of Drosophila germline stem cell sexual identity in oogenesis and tumorigenesis.Development (Cambridge, England) · 2015Article
- The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates.BMC evolutionary biology · 2015Article
- Article
- Adaptive evolution of testis-specific, recently evolved, clustered miRNAs in Drosophila.RNA (New York, N.Y.) · 2014Article
- Two Arabidopsis loci encode novel eukaryotic initiation factor 4E isoforms that are functionally distinct from the conserved plant eukaryotic initiation factor 4E.Plant physiology · 2014Article
- The meiotic transcriptome architecture of plants.Frontiers in plant science · 2014Review
- Mutations in eIF4ENIF1 are associated with primary ovarian insufficiency.The Journal of clinical endocrinology and metabolism · 2013Article
- Lessons for inductive germline determination.Molecular reproduction and development · 2013Review
- Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster.Molecular and cellular biology · 2013Article
- eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The Distribution of eIF4E-Family Members across Insecta.Comparative and functional genomics · 2012Article
- Separating from the pack: Molecular mechanisms ofSpermatogenesisArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Gene expression is translationally regulated during many cellular and developmental processes. Translation can be modulated by affecting the recruitment of mRNAs to the ribosome, which involves recognition of the 5' cap structure by the cap-binding protein eIF4E. Drosophila has several genes encoding eIF4E-related proteins, but the biological role of most of them remains unknown. Here, we report that Drosophila eIF4E-3 is required specifically during spermatogenesis. Males lacking eIF4E-3 are sterile, showing defects in meiotic chromosome segregation, cytokinesis, nuclear shaping and individualization. We show that eIF4E-3 physically interacts with both eIF4G and eIF4G-2, the latter being a factor crucial for spermatocyte meiosis. In eIF4E-3 mutant testes, many proteins are present at different levels than in wild type, suggesting widespread effects on translation. Our results imply that eIF4E-3 forms specific eIF4F complexes that are essential for spermatogenesis.
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