ArticleJournal of biomolecular NMR2012
Compressed sensing reconstruction of undersampled 3D NOESY spectra: application to large membrane proteins.
Article in Journal of biomolecular NMR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Backbone and side‑chainBiomolecular NMR assignments · 2025Article
- A DNA condensation code for linker histones.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- nus-tool: A unified program for generating and analyzing sample schedules for nonuniformly sampled NMR experiments.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- Phosphorylation of the smooth muscle master splicing regulator RBPMS regulates its splicing activity.Nucleic acids research · 2022Article
- Clustered sparsity and Poisson-gap sampling.Journal of biomolecular NMR · 2021Article
- A simple approach for reconstruction of non-uniformly sampled pseudo-3D NMR data for accurate measurement of spin relaxation parameters.Journal of biomolecular NMR · 2021Article
- NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR.Magnetic resonance (Gottingen, Germany) · 2021Article
- Reducing the measurement time of exact NOEs by non-uniform sampling.Journal of biomolecular NMR · 2020Article
- Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase.Antimicrobial agents and chemotherapy · 2020Article
- Amino-acid selective isotope labeling enables simultaneous overlapping signal decomposition and information extraction from NMR spectra.Journal of biomolecular NMR · 2020Article
- Importance of time-ordered non-uniform sampling of multi-dimensional NMR spectra of AβJournal of biomolecular NMR · 2019Article
- Insight into partial agonism by observing multiple equilibria for ligand-bound and GNature communications · 2017Article
- Sparse multidimensional iterative lineshape-enhanced (SMILE) reconstruction of both non-uniformly sampled and conventional NMR data.Journal of biomolecular NMR · 2017Article
- Improving resolution in multidimensional NMR using random quadrature detection with compressed sensing reconstruction.Journal of biomolecular NMR · 2017Article
- A new approach to compressed sensing for NMR.Magnetic resonance in chemistry : MRC · 2015Article
- Non-Uniform Sampling and J-UNIO Automation for Efficient Protein NMR Structure Determination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Compressed sensing to accelerate magnetic resonance spectroscopic imaging: evaluation and application to 23Na-imaging of mouse hearts.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015Article
- Sensitivity of nonuniform sampling NMR.The journal of physical chemistry. B · 2015Article
- Development of a method for reconstruction of crowded NMR spectra from undersampled time-domain data.Journal of biomolecular NMR · 2015Article
- Efficient and generalized processing of multidimensional NUS NMR data: the NESTA algorithm and comparison of regularization terms.Journal of biomolecular NMR · 2015Article
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3 authors.
Funding
Abstract
Central to structural studies of biomolecules are multidimensional experiments. These are lengthy to record due to the requirement to sample the full Nyquist grid. Time savings can be achieved through undersampling the indirectly-detected dimensions combined with non-Fourier Transform (FT) processing, provided the experimental signal-to-noise ratio is sufficient. Alternatively, resolution and signal-to-noise can be improved within a given experiment time. However, non-FT based reconstruction of undersampled spectra that encompass a wide signal dynamic range is strongly impeded by the non-linear behaviour of many methods, which further compromises the detection of weak peaks. Here we show, through an application to a larger α-helical membrane protein under crowded spectral conditions, the potential use of compressed sensing (CS) l (1)-norm minimization to reconstruct undersampled 3D NOESY spectra. Substantial signal overlap and low sensitivity make this a demanding application, which strongly benefits from the improvements in signal-to-noise and resolution per unit time achieved through the undersampling approach. The quality of the reconstructions is assessed under varying conditions. We show that the CS approach is robust to noise and, despite significant spectral overlap, is able to reconstruct high quality spectra from data sets recorded in far less than half the amount of time required for regular sampling.
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