Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed.

1. Targeting the Lin28/let-7 Axis with Compounds to Regulate Transcriptional Control in Cancer.Anti-cancer agents in medicinal chemistry · 2026
   Review
2. Metabolism and immunity in breast cancer.Frontiers of medicine · 2021
   Review
3. Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner.Oncology letters · 2018
   Article
4. Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
   Article
5. Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer.Molecular cancer · 2015
   Review
6. Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response.PloS one · 2015
   Article
7. Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma.Oncotarget · 2015
   Article
8. Lin28 promotes Her2 expression and Lin28/Her2 predicts poorer survival in gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
   Article
9. Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.Oncotarget · 2014
   Review
10. Breast cancer stem cells: Multiple capacities in tumor metastasis.Cancer letters · 2014
    Review
11. Far beyond the usual biomarkers in breast cancer: a review.Journal of Cancer · 2014
    Review
12. Breast cancer adaptive resistance: HER2 and cancer stem cell repopulation in a heterogeneous tumor society.Journal of cancer research and clinical oncology · 2014
    Review
13. Genetic and epigenetic analysis of putative breast cancer stem cell models.BMC cancer · 2013
    Article
14. The role of radiotherapy-resistant stem cells in breast cancer recurrence.Breast cancer management
    Article

Corrections and comments

• Comment on
  Lin28 regulates HER2 and promotes malignancy through multiple mechanisms.2012

Authors and funding

4 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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