ReviewNeuroscience bulletin2012
Axonal bleb recording.
Review in Neuroscience bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Article
- Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons.bioRxiv : the preprint server for biology · 2026Article
- Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.Proceedings. Biological sciences · 2025Review
- Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment.PLoS computational biology · 2024Article
- Detection and verification of neurodegeneration after traumatic brain injury in the mouse: Immunohistochemical staining for amyloid precursor protein.Brain pathology (Zurich, Switzerland) · 2023Article
- Bi-directional Control of Synaptic Input Summation and Spike Generation by GABAergic Inputs at the Axon Initial Segment.Neuroscience bulletin · 2023Article
- Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models.Science advances · 2022Article
- Differences in action potential propagation speed and axon initial segment plasticity between neurons from Sprague-Dawley rats and C57BL/6 mice.Zoological research · 2022Article
- Functional Neuroanatomy of the Rat Nucleus Incertus-Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway.Frontiers in cellular neuroscience · 2022Article
- Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array.Frontiers in neuroscience · 2022Article
- Advantages, Pitfalls, and Developments of All Optical Interrogation Strategies of MicrocircuitsFrontiers in neuroscience · 2022Review
- Article
- Action potential propagation and synchronisation in myelinated axons.PLoS computational biology · 2019Article
- Neuromodulation of Axon Terminals.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Differential roles of NaScientific reports · 2018Article
- Review
- Dual face of axonal inhibitory inputs in the modulation of neuronal excitability in cortical pyramidal neurons.Neural regeneration research · 2017Article
- Axonal activity in vivo: technical considerations and implications for the exploration of neural circuits in freely moving animals.Frontiers in neuroscience · 2015Review
- Hippocampal "cholinergic interneurons" visualized with the choline acetyltransferase promoter: anatomical distribution, intrinsic membrane properties, neurochemical characteristics, and capacity for cholinergic modulation.Frontiers in synaptic neuroscience · 2015Article
- Action potential initiation in neocortical inhibitory interneurons.PLoS biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patch-clamp recording requires direct accessibility of the cell membrane to patch pipettes and allows the investigation of ion channel properties and functions in specific cellular compartments. The cell body and relatively thick dendrites are the most accessible compartments of a neuron, due to their large diameters and therefore great membrane surface areas. However, axons are normally inaccessible to patch pipettes because of their thin structure; thus studies of axon physiology have long been hampered by the lack of axon recording methods. Recently, a new method of patch-clamp recording has been developed, enabling direct and tight-seal recording from cortical axons. These recordings are performed at the enlarged structure (axonal bleb) formed at the cut end of an axon after slicing procedures. This method has facilitated studies of the mechanisms underlying the generation and propagation of the main output signal, the action potential, and led to the finding that cortical neurons communicate not only in action potential-mediated digital mode but also in membrane potential-dependent analog mode.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.