SynthesisTranslational psychiatry2012
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
Synthesis in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism.Journal of human genetics · 2017Pooled it
- Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.Behavior genetics · 2016Pooled it
- GWA meta-analysis of personality in Korean cohorts.Journal of human genetics · 2015Pooled it
- Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.JAMA psychiatry · 2015Pooled it
- Dual-systems models of the genetic architecture of impulsive personality traits: neurogenetic evidence of distinct but related factors.Psychological medicine · 2024Article
- Personality subtypes in adults with social anxiety disorder - novelty seeking makes the difference.BMC psychiatry · 2022Article
- Understanding Anhedonia from a Genomic Perspective.Current topics in behavioral neurosciences · 2022Review
- Uncovering the complex genetics of human temperament.Molecular psychiatry · 2020Article
- Uncovering the complex genetics of human character.Molecular psychiatry · 2020Article
- Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank.Nature communications · 2020Article
- Modeling human temperament and character on the basis of combined theoretical approaches.Annals of general psychiatry · 2019Article
- What is the natural measurement unit of temperament: single traits or profiles?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Genetics of biologically based psychological differences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- The genetics of human personality.Genes, brain, and behavior · 2018Review
- Modeling prior information of common genetic variants improves gene discovery for neuroticism.Human molecular genetics · 2017Article
- Identification of genetic loci shared between schizophrenia and the Big Five personality traits.Scientific reports · 2017Article
- GWAS for executive function and processing speed suggests involvement of the CADM2 gene.Molecular psychiatry · 2016Article
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory.Behavior genetics · 2014Article
- Personality traits of the Five-Factor Model are associated with work-related stress in special force police officers.International archives of occupational and environmental health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 15 institutions in 4 countries.
Funding
Abstract
Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons with genome-wide genotype data, who have been assessed with Cloninger's Temperament and Character Inventory. Sum scores for novelty seeking, harm avoidance, reward dependence and persistence have been measured in over 11,000 persons collected in four different cohorts. Our study had >80% power to identify genome-wide significant loci (P<1.25 × 10(-8), with correction for testing four scales) accounting for ≥0.4% of the phenotypic variance in temperament scales. Using meta-analysis techniques, gene-based tests and pathway analysis we have tested over 1.2 million single-nucleotide polymorphisms (SNPs) for association to each of the four temperament dimensions. We did not discover any SNPs, genes, or pathways to be significantly related to the four temperament dimensions, after correcting for multiple testing. Less than 1% of the variability in any temperament dimension appears to be accounted for by a risk score derived from the SNPs showing strongest association to the temperament dimensions. Elucidation of genetic loci significantly influencing temperament and personality will require potentially very large samples, and/or a more refined phenotype. Item response theory methodology may be a way to incorporate data from cohorts assessed with multiple personality instruments, and might be a method by which a large sample of a more refined phenotype could be acquired.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.