ArticleTranslational psychiatry2012
Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders.
Article in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.Early intervention in psychiatry · 2020Pooled it
- Article
- Assessment of the Precision in Measuring Glutathione at 3 T With a MEGA-PRESS Sequence in Primary Motor Cortex and Occipital Cortex.Journal of magnetic resonance imaging : JMRI · 2022Article
- Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?Antioxidants (Basel, Switzerland) · 2021Review
- In Vivo Brain GSH: MRS Methods and Clinical Applications.Antioxidants (Basel, Switzerland) · 2021Review
- Glutathione as a Molecular Marker of Functional Impairment in Patients with At-Risk Mental State: 7-TeslaBrain sciences · 2021Article
- Article
- Protocol for a young adult mental health (Uspace) cohort: personalising multidimensional care in young people admitted to hospital.BMJ open · 2021Article
- Counteracting Effects of Glutathione on the Glutamate-Driven Excitation/Inhibition Imbalance in First-Episode Schizophrenia: A 7T MRS and Dynamic Causal Modeling Study.Antioxidants (Basel, Switzerland) · 2021Article
- Schizophrenia Increases Variability of the Central Antioxidant System: A Meta-Analysis of Variance From MRS Studies of Glutathione.Frontiers in psychiatry · 2021Review
- Interaction of Serum Copper and Neurometabolites on Executive Dysfunction in Unmedicated Patients With Major Depressive Disorder.Frontiers in psychiatry · 2021Article
- Article
- In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders.European archives of psychiatry and clinical neuroscience · 2018Article
- Glutamatergic metabolites among adolescents at risk for psychosis.Psychiatry research · 2017Article
- Delayed circadian phase is linked to glutamatergic functions in young people with affective disorders: a proton magnetic resonance spectroscopy study.BMC psychiatry · 2014Article
- Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy.Psychopharmacology · 2014Article
- Clinical classification in mental health at the cross-roads: which direction next?BMC medicine · 2013Article
- Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation.PloS one · 2013Article
- Prefrontal lactate predicts exercise-induced cognitive dysfunction in Gulf War Illness.American journal of translational research · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, there are no validated neurobiological methods for distinguishing different pathophysiological pathways in young patients presenting in the early phases of major psychiatric disorders. Hence, treatments are delivered simply on the basis of their possible effects on nonspecific symptom constructs such as depression, cognitive change or psychotic symptoms. In this study, the ratios (relative to creatine) of key metabolites (N-acetyl aspartate, myoinositol, glutamate and glutathione) were measured with proton magnetic resonance spectroscopy ((1)H-MRS) within the anterior cingulate cortex of 88 young persons presenting with major mood or psychotic symptoms. We derived empirically (using a cluster analytical technique) three subgroups of subjects on the basis of their patterns of in vivo brain biochemistry. The three subgroups were distinguished (from each other) by all the four metabolites, in particular, glutathione and glutamate. By contrast, the groups could not be distinguished by differences in terms of other demographic, functional or clinical measures. We propose that this (1)H-MRS-based subclassification system could be used as the basis for much more specific tests of novel intervention strategies (notably, antioxidant and glutamatergic therapies) early in the course of major psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.