ArticleTranslational psychiatry2012
Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion.
Article in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 8 syntheses or guidelines pooled it, 184 citations in OpenAlex.
- Personality characteristics below facets: A replication and meta-analysis of cross-rater agreement, rank-order stability, heritability, and utility of personality nuances.Journal of personality and social psychology · 2019Pooled it
- Evaluation of the Genetic Variance of Alzheimer's Disease Explained by the Disease-Associated Chromosomal Regions.Journal of Alzheimer's disease : JAD · 2019Pooled it
- Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.Molecular psychiatry · 2016Pooled it
- Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.Behavior genetics · 2016Pooled it
- Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.JAMA psychiatry · 2015Pooled it
- Genetic and environmental continuity in personality development: a meta-analysis.Psychological bulletin · 2014Pooled it
- The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.Addiction biology · 2013Pooled it
- The molecular genetic architecture of self-employment.PloS one · 2013Pooled it
- Trial
- Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets.BMC medical genomics · 2023Article
- Genetic variation in chromatin state across multiple tissues in Drosophila melanogaster.PLoS genetics · 2023Article
- Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.Biological psychiatry · 2023Article
- Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population.BMC genomics · 2021Article
- Genetic predictors of educational attainment and intelligence test performance predict voter turnout.Nature human behaviour · 2021Article
- The influence of X chromosome variants on trait neuroticism.Molecular psychiatry · 2021Article
- The Differential Heritability of Social Adjustment by Sex.International journal of environmental research and public health · 2021Article
- Exploring the Genetic Underpinnings of Aggression inJournal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2021Article
- The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings.Translational psychiatry · 2019Review
- The Genome-Wide Study of Human Social Behavior and Its Application in Sociology.Frontiers in sociology · 2019Review
- Genomic analysis of family data reveals additional genetic effects on intelligence and personality.Molecular psychiatry · 2018Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 6 institutions in 4 countries.
Funding
Abstract
The personality traits of neuroticism and extraversion are predictive of a number of social and behavioural outcomes and psychiatric disorders. Twin and family studies have reported moderate heritability estimates for both traits. Few associations have been reported between genetic variants and neuroticism/extraversion, but hardly any have been replicated. Moreover, the ones that have been replicated explain only a small proportion of the heritability (<~2%). Using genome-wide single-nucleotide polymorphism (SNP) data from ~12,000 unrelated individuals we estimated the proportion of phenotypic variance explained by variants in linkage disequilibrium with common SNPs as 0.06 (s.e. = 0.03) for neuroticism and 0.12 (s.e. = 0.03) for extraversion. In an additional series of analyses in a family-based sample, we show that while for both traits ~45% of the phenotypic variance can be explained by pedigree data (that is, expected genetic similarity) one third of this can be explained by SNP data (that is, realized genetic similarity). A part of the so-called 'missing heritability' has now been accounted for, but some of the reported heritability is still unexplained. Possible explanations for the remaining missing heritability are that: (i) rare variants that are not captured by common SNPs on current genotype platforms make a major contribution; and/ or (ii) the estimates of narrow sense heritability from twin and family studies are biased upwards, for example, by not properly accounting for nonadditive genetic factors and/or (common) environmental factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.