ArticleTranslational psychiatry2012
Human fear reconsolidation and allelic differences in serotonergic and dopaminergic genes.
Article in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Harnessing reconsolidation to weaken fear and appetitive memories: A meta-analysis of post-retrieval extinction effects.Psychological bulletin · 2016Pooled it
- Effect of app-based mindfulness on extinction recall - a 7T-fMRI study.Scientific reports · 2026Trial
- The effect of mindfulness training on extinction retention.Scientific reports · 2019Trial
- Fear expression is suppressed by tyrosine administration.Scientific reports · 2019Trial
- Modification of Fear Memory by Pharmacological and Behavioural Interventions during Reconsolidation.PloS one · 2016Trial
- Disrupting reconsolidation of fear memory in humans by a noradrenergic β-blocker.Journal of visualized experiments : JoVE · 2014Trial
- Genetic polymorphisms in monoamine systems and outcome of cognitive behavior therapy for social anxiety disorder.PloS one · 2013Trial
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- More and Less Fear in Serotonin Transporter Knockout Mice.Genes, brain, and behavior · 2025Article
- Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics.Neuroscience bulletin · 2025Review
- Carbon Dioxide Reactivity Differentially Predicts Fear Expression After Extinction and Retrieval-Extinction in Rats.Biological psychiatry global open science · 2024Article
- The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies.Brain sciences · 2023Review
- Testing the memory reconsolidation hypothesis in a fear extinction paradigm: The effects of ecological and arbitrary stimuli.Learning & behavior · 2022Article
- Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.Scientific reports · 2020Article
- Impact of a reminder/extinction procedure on threat-conditioned pupil size and skin conductance responses.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- From Extinction Learning to Anxiety Treatment: Mind the Gap.Brain sciences · 2019Article
- Impaired fear extinction in serotonin transporter knockout rats is associated with increased 5-hydroxymethylcytosine in the amygdala.CNS neuroscience & therapeutics · 2018Article
- A reminder before extinction strengthens episodic memory via reconsolidation but fails to disrupt generalized threat responses.Scientific reports · 2017Article
- Extinction after fear memory reactivation fails to eliminate renewal in rats.Neurobiology of learning and memory · 2017Article
- An Update on Memory Reconsolidation Updating.Trends in cognitive sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fear memory persistence, central for the development and maintenance of anxiety disorders, is partially genetically controlled. Recently, consolidation and reconsolidation processes have been reported to affect fear memory stability and integrity. This study explored the impact of reconsolidation processes and genetic make-up on fear reacquisition by manipulating reconsolidation, using extinction performed outside or inside a reconsolidation interval. Reacquisition measured by skin conductance responses was stronger in individuals that extinguished outside (6 h) than inside (10 min) the reconsolidation interval. However, the effect was predominantly present in val/val homozygotes of the functional val158met polymorphism of the catechol O-methyltransferase (COMT) enzyme and in short-allele carriers of the serotonin-transporter length 5-HTTLPR polymorphism. These results demonstrate that reconsolidation of human fear memory is influenced by dopamine and serotonin-related genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.