ArticleTranslational psychiatry2012
BDNF val66met affects hippocampal volume and emotion-related hippocampal memory activity.
Article in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Imaging genetics paradigms in depression research: Systematic review and meta-analysis.Progress in neuro-psychopharmacology & biological psychiatry · 2018Pooled it
- Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review.Brain and behavior · 2018Pooled it
- Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples.NeuroImage. Clinical · 2017Pooled it
- Pooled it
- Gene-Physical Activity Interplay in Depression: Candidate-Gene Interactions, Polygenic Susceptibility, Lifestyle Context, and Mendelian Randomization Evidence-Systematic Review.Journal of clinical medicine · 2026Review
- Genetic Polymorphisms Associated with Lithium Response in Bipolar Disorder: An Integrative Review and In Silico Protein-Protein Interaction Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The impact of the BDNF Val66Met genotype on intrusive memories following trauma exposure and in PTSD is moderated by sex and timing of trauma exposure.Scientific reports · 2025Article
- Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance.International journal of molecular sciences · 2024Review
- The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder.Scientific reports · 2023Article
- Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population.International journal of molecular sciences · 2023Article
- Depression in Adolescence and Brain-Derived Neurotrophic Factor.Frontiers in molecular neuroscience · 2022Review
- Depressive Emotionality Moderates the Influence of the BDNF Val66Met Polymorphism on Executive Functions and on Unconscious Semantic Priming.Journal of molecular neuroscience : MN · 2020Article
- The role of genetics in cognitive remediation in schizophrenia: A systematic review.Schizophrenia research. Cognition · 2020Review
- Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study.Brain communications · 2020Article
- Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice.Psychopharmacology · 2019Article
- Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder.European archives of psychiatry and clinical neuroscience · 2019Article
- A single-nucleotide polymorphism influences brain morphology in drug-naïve patients with major depressive disorder.Neuropsychiatric disease and treatment · 2019Article
- Brain-Derived Neurotrophic Factor Val66Met Polymorphism Is Associated With a Reduced ERP Component Indexing Emotional Recollection.Frontiers in psychology · 2019Article
- BDNF genotype is associated with hippocampal volume in mild traumatic brain injury.Genes, brain, and behavior · 2018Article
- The antidepressant efficacy of subanesthetic-dose ketamine does not correlate with baseline subcortical volumes in a replication sample with major depressive disorder.Journal of psychopharmacology (Oxford, England) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The val(66)met polymorphism on the BDNF gene has been reported to explain individual differences in hippocampal volume and memory-related activity. These findings, however, have not been replicated consistently and no studies to date controlled for the potentially confounding impact of early life stress, such as childhood abuse, and psychiatric status. Using structural and functional MRI, we therefore investigated in 126 depressed and/or anxious patients and 31 healthy control subjects the effects of val(66)met on hippocampal volume and encoding activity of neutral, positive and negative words, while taking into account childhood abuse and psychiatric status. Our results show slightly lower hippocampal volumes in carriers of a met allele (n=54) relative to val/val homozygotes (n=103) (P=0.02, effect size (Cohen's d)=0.37), which appeared to be independent of childhood abuse and psychiatric status. For hippocampal encoding activity, we found a val(66)met-word valence interaction (P=0.02) such that carriers of a met allele showed increased levels of activation in response to negative words relative to activation in the neutral word condition and relative to val/val homozygotes. This, however, was only evident in the absence of childhood abuse, as abused val/val homozygotes showed hippocampal encoding activity for negative words that was comparable to that of carriers of a met allele. Neither psychiatric status nor memory accuracy did account for these associations. In conclusion, BDNF val(66)met has a significant impact on hippocampal volume independently of childhood abuse and psychiatric status. Furthermore, early adverse experiences such as childhood abuse account for individual differences in hippocampal encoding activity of negative stimuli but this effect manifests differently as a function of val(66)met.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.