ArticleTranslational psychiatry2011
Increased de novo copy number variants in the offspring of older males.
Article in Translational psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Transposon insertion profiling by sequencing (TIPseq) identifies novel LINE-1 insertions in human sperm.Journal of assisted reproduction and genetics · 2023Article
- Paternal age and specific neurological soft signs as reliable and valid neurobiological markers for the diagnosis of patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
- Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations.Journal of clinical medicine · 2019Review
- Small de novo CNVs as biomarkers of parental exposure to low doses of ionizing radiation of caesium-137.Scientific reports · 2018Article
- Autism risk associated with parental age and with increasing difference in age between the parents.Molecular psychiatry · 2016Article
- Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.The Journal of experimental medicine · 2016Article
- Comparative two-dimensional polyacrylamide gel electrophoresis of the salivary proteome of children with autism spectrum disorder.Journal of cellular and molecular medicine · 2015Article
- Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression.Molecular psychiatry · 2015Article
- Parental Age at Birth and Risk of Hematological Malignancies in Older Adults.American journal of epidemiology · 2015Article
- The 4th Schizophrenia International Research Society Conference, 5-9 April 2014, Florence, Italy: a summary of topics and trends.Schizophrenia research · 2014Article
- Transcriptomic changes in the frontal cortex associated with paternal age.Molecular autism · 2014Article
- The effect of paternal age on offspring intelligence and personality when controlling for paternal trait level.PloS one · 2014Article
- Non-telomeric epigenetic and genetic changes are associated with the inheritance of shorter telomeres in mice.Chromosoma · 2013Article
- The role of AUTS2 in neurodevelopment and human evolution.Trends in genetics : TIG · 2013Review
- "Selfish spermatogonial selection": a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders.The American journal of psychiatry · 2013Review
- Autism risk across generations: a population-based study of advancing grandpaternal and paternal age.JAMA psychiatry · 2013Article
- Ageing of the male germ line.Nature reviews. Urology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The offspring of older fathers have an increased risk of neurodevelopmental disorders, such as schizophrenia and autism. In light of the evidence implicating copy number variants (CNVs) with schizophrenia and autism, we used a mouse model to explore the hypothesis that the offspring of older males have an increased risk of de novo CNVs. C57BL/6J sires that were 3- and 12-16-months old were mated with 3-month-old dams to create control offspring and offspring of old sires, respectively. Applying genome-wide microarray screening technology, 7 distinct CNVs were identified in a set of 12 offspring and their parents. Competitive quantitative PCR confirmed these CNVs in the original set and also established their frequency in an independent set of 77 offspring and their parents. On the basis of the combined samples, six de novo CNVs were detected in the offspring of older sires, whereas none were detected in the control group. Two of the CNVs were associated with behavioral and/or neuroanatomical phenotypic features. One of the de novo CNVs involved Auts2 (autism susceptibility candidate 2), and other CNVs included genes linked to schizophrenia, autism and brain development. This is the first experimental demonstration that the offspring of older males have an increased risk of de novo CNVs. Our results support the hypothesis that the offspring of older fathers have an increased risk of neurodevelopmental disorders such as schizophrenia and autism by generation of de novo CNVs in the male germline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.