ArticleWorld journal of urology2013
Standardization of isothermal microcalorimetry in urinary tract infection detection by using artificial urine.
Article in World journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- A novel urine collection device for accurate urinary measurements in neonates and pre-continent infants.Pediatric research · 2026Article
- Advancing diagnostics in suspected periprosthetic joint infections using synthetic synovial fluid and microcalorimetry.Journal of bone and joint infection · 2026Article
- A Machine Learning Approach to Microcalorimetric Pattern Classification of Pathogens in Synovial Fluid.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Isothermal microcalorimetry improves accuracy and time to bacterial detection of periprosthetic joint infection after total joint arthroplasty.Journal of clinical microbiology · 2023Article
- Dehydration Tolerance in Epidemic versus Nonepidemic MRSA Demonstrated by Isothermal Microcalorimetry.Microbiology spectrum · 2022Article
- A Method to Determine the Efficacy of a Commercial Phage Preparation against Uropathogens in Urine and Artificial Urine Determined by Isothermal Microcalorimetry.Microorganisms · 2022Article
- Quantitative determination of leukocyte esterase with a paper-based device.RSC advances · 2020Article
- Rapid Calorimetric Detection of Bacterial Contamination: Influence of the Cultivation Technique.Frontiers in microbiology · 2019Article
- Seven hours to adequate antimicrobial therapy in urosepsis using isothermal microcalorimetry.Journal of clinical microbiology · 2014Article
- [Areas of application of isothermal microcalorimetry in urology: an overview].Der Urologe. Ausg. A · 2013Review
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIsothermal microcalorimetry (IMC) has recently been reported as a new method to rapidly detect urinary tract pathogens (UTP). However, further application of microcalorimetry in the clinical setting requires a standardized procedure. An important step toward such standardization is to use a reproducible growth medium. In this study, we investigated the potential of artificial urine in combination with microcalorimetry for detection of common UTP.
methodsA microcalorimeter equipped with 48 channels was used. Detection was accomplished, and growth was monitored for four bacterial strains in artificial urine at 37 °C by measuring metabolic heat flow (μW = μJ/s) as a function of time. The strains were Escherichia coli, Proteus mirabilis, Enterococcus faecalis, and Staphylococcus aureus.
resultBacterial growth was detected after 3-32 h with decreasing inoculums down to 1 CFU. The gram-negative strains grew and were detected faster than their gram-positive counterparts. The growth rates the different strains were 0.75 ± 0.11 for E. coli, 0.74 ± 0.10 for E. faecalis, 1.31 ± 0.04 for P. mirabilis, and 0.56 ± 0.20 for S. aureus. The shape of individual heat flow curves was characteristic for each species independent of its initial concentration.
conclusionsIMC allows rapid detection of UTP in artificial urine. Clearly, different heat flow patterns enable accurate pathogen differentiation. UTP detection after only 4 h is realistic. The rapid detection of UTP tested in standardized artificial urine proves the diagnostic potential of IMC and warrants further microcalorimetric studies in the clinical setting of urinary tract infections.
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