ArticleTranslational psychiatry2011
Decanalization, brain development and risk of schizophrenia.
Article in Translational psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of prenatal and perinatal factors in eating disorders: a systematic review.Archives of women's mental health · 2021Pooled it
- Canalization of neural dynamics by δ-protocadherins in the developing zebrafish optic tectum.PLoS genetics · 2026Article
- The impact of placental genomic risk for schizophrenia and birth asphyxia on brain development.Translational psychiatry · 2023Article
- Mechanisms of robustness in gene regulatory networks involved in neural development.Frontiers in molecular neuroscience · 2023Review
- Isolation disrupts social interactions and destabilizes brain development in bumblebees.Current biology : CB · 2022Article
- Review of rodent models of attention deficit hyperactivity disorder.Neuroscience and biobehavioral reviews · 2022Review
- Change of pace: How developmental tempo varies to accommodate failed provision of early needs.Neuroscience and biobehavioral reviews · 2021Review
- Placental genomic risk scores and early neurodevelopmental outcomes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Behavior-related gene regulatory networks: A new level of organization in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Genomic Variation, Evolvability, and the Paradox of Mental Illness.Frontiers in psychiatry · 2020Article
- Beyond Royalactin and a master inducer explanation of phenotypic plasticity in honey bees.Communications biology · 2018Review
- Prioritized High-Confidence Risk Genes for Intellectual Disability Reveal Molecular Convergence During Brain Development.Frontiers in genetics · 2018Article
- Socio-Genomics and Structural Competency.Journal of bioethical inquiry · 2016Article
- The Role of Epigenetic Change in Autism Spectrum Disorders.Frontiers in neurology · 2015Review
- Identifying novel interventional strategies for psychiatric disorders: integrating genomics, 'enviromics' and gene-environment interactions in valid preclinical models.British journal of pharmacology · 2014Review
- Circadian rhythms and mood: opportunities for multi-level analyses in genomics and neuroscience: circadian rhythm dysregulation in mood disorders provides clues to the brain's organizing principles, and a touchstone for genomics and neuroscience.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- A simulation study of gene-by-environment interactions in GWAS implies ample hidden effects.Frontiers in genetics · 2014Article
- Chromatin regulators, phenotypic robustness, and autism risk.Frontiers in genetics · 2014Article
- Decanalization mediating gene-environment interactions in schizophrenia and other psychiatric disorders with neurodevelopmental etiology.Frontiers in behavioral neuroscience · 2013Article
- Increased de novo copy number variants in the offspring of older males.Translational psychiatry · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Waddington's original description of canalization refers to the ability of an organism to maintain phenotypic fidelity in the face of environmental and/or genetic perturbation. Development of the human brain requires exposure to a 'wild-type' environment-one that supports the optimal set of instructions for development. Recently derived brain structures in our species, such as the expanded neocortex, may be more vulnerable to decanalization because there has been insufficient time to evolve buffering capacity. On the basis of modern notions of decanalization, we provide perspectives on selected environmental and genetic risk factors for schizophrenia, and we discuss strengths and weaknesses of this conceptual framework. We argue that if we are to build a solid foundation for translational psychiatry, we must explore models that attempt to capture the complexity of the interaction between genetic and non-genetic risk factors in mediating and modulating brain development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.