Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2012
The effects of age and estrogen on stress responsivity in older women.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Estradiol and non-REM sleep attenuate physiological and emotional responses to social-evaluative stress in healthy women.BMC medicine · 2025Article
- Association between chronic stress-related amygdala metabolic activity and lymph node metastasis in endometrial cancer.Scientific reports · 2024Article
- Disarranged neuroplastin environment upon aging and chronic stress recovery in female Sprague Dawley rats.The European journal of neuroscience · 2022Article
- Differential effects of estradiol on neural and emotional stress response in postmenopausal women with remitted Major Depressive Disorder.Journal of affective disorders · 2021Article
- Estrogen attenuates physical and psychological stress-induced cognitive impairments in ovariectomized rats.Brain and behavior · 2021Article
- Human immunodeficiency: Extragonadal comorbidities of infertility in women.Immunity, inflammation and disease · 2020Review
- What Does Sex Have to Do with It? The Role of Sex as a Biological Variable in the Development of Posttraumatic Stress Disorder.Current psychiatry reports · 2018Review
- Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population.Current neuropharmacology · 2018Review
- Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition.The Journal of clinical psychiatry · 2017Article
- Sex as a Biological Variable: Who, What, When, Why, and How.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Sex differences and stress across the lifespan.Nature neuroscience · 2015Review
- Hormone therapy use in women veterans accessing veterans health administration care: a national cross-sectional study.Journal of general internal medicine · 2015Article
- Functional and molecular neuroimaging of menopause and hormone replacement therapy.Frontiers in neuroscience · 2014Review
- The role of maternal stress in early pregnancy in the aetiology of gastroschisis: an incident case control study.PloS one · 2013Article
- Stress, inflammation, and aging.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2012Article
- Dancing Queen… Only seventy! the short- and long-term effects of older-women group dancing on self-esteem, depression, and self-judgment.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe current study examined whether age after menopause impacted the effect of estradiol (E2) on mood after a psychosocial stress manipulation.
backgroundPrevious studies have shown that E2 improves mood in women around the menopause transition but does not improve mood for older postmenopausal women. We have previously shown that E2 treatment in nondepressed women resulted in increased negative mood after psychosocial stress.
designParticipants were 22 postmenopausal women placed on either oral placebo or 17β-estradiol (1 mg/day for 1 month, then 2 mg/day for 2 months).
methodAt the end of the 3-month treatment phase, the participants performed the Trier Social Stress Test followed by mood ratings. To examine the effects of age on the estrogen-stress interaction, we performed a median split on age and created four groups of participants: younger-placebo (mean age: 55.5 years), younger-E2 (mean age: 55.5 years), older-placebo (mean age: 73.0 years), and older-E2 (mean age: 76.8 years).
results: The results showed that both older and younger E2-treated participants exhibited a significant and similar increase in negative mood after psychosocial stress compared with placebo-treated women.
conclusionsThese results suggest that E2 may play a significant role in modulating emotional reactivity to stressful events and that this effect persists in older women. Furthermore, responsivity to E2 effects on emotional processing appears to be intact even years after menopause in contrast with other cognitive and behavioral effects of E2, which may be limited to the early postmenopausal years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.